Trial reportSchizophrenia research2019
Sleep duration and psychotic experiences in patients at risk of psychosis: A secondary analysis of the EDIE-2 trial.
Trial report in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Interindividual Sleep Variability Across the Psychosis Spectrum: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Digital sleep phenotype and wrist actigraphy in individuals at clinical high risk for psychosis and people with schizophrenia spectrum disorders: a systematic review and meta-analysis.BMJ mental health · 2025Pooled it
- Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials.Sleep medicine reviews · 2021Pooled it
- Sleep and schizophrenia: From epiphenomenon to treatable causal target.Schizophrenia research · 2020Pooled it
- Sleep disturbance as a marker of postpartum psychosis risk: a prospective actigraphy study.BMC psychiatry · 2025Observational
- Bidirectional associations between short sleep duration, insomnia symptoms, and psychotic-like experiences in adolescents.European child & adolescent psychiatry · 2025Article
- Ethical challenges in contemporary psychiatry: an overview and an appraisal of possible strategies and research needs.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- The role of sleep disturbances in the onset and maintenance of psychiatric disorders in childhood and adolescence: A review of subjective and polysomnographic findings.Current sleep medicine reports · 2024Article
- Associations between disturbed sleep and attenuated psychotic experiences in people at clinical high risk for psychosis.Psychological medicine · 2024Article
- Impaired Sleep Mediates the Relationship Between Interpersonal Trauma and Subtypes of Delusional Ideation.Schizophrenia bulletin · 2024Article
- Alexithymia is associated with insomnia in Chinese patients with schizophrenia.Frontiers in psychiatry · 2023Article
- Adolescent sleep and the foundations of prefrontal cortical development and dysfunction.Progress in neurobiology · 2022Review
- Sleep Disturbance in Individuals at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2022Article
- The nature, consequences, mechanisms, and management of sleep disturbances in individuals at-risk for psychosis.Frontiers in psychiatry · 2022Review
- Examining self-reported social functioning, sleep quality, and psychotic-like experiences in college students.Journal of psychiatric research · 2021Article
- Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.The American journal of psychiatry · 2021Review
- Article
- Sleep disturbance and sleep-related impairment in psychotic disorders are related to both positive and negative symptoms.Psychiatry research · 2020Article
- Sleep Problems and Social Impairment in Psychosis: A Transdiagnostic Study Examining Multiple Social Domains.Frontiers in psychiatry · 2020Article
- Sleep problems and attenuated psychotic symptoms in youth at clinical high-risk for psychosis.Psychiatry research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Sleep disturbance is common among individuals at risk of psychosis, yet few studies have investigated the relationship between sleep disturbance and clinical trajectory. The Early Detection and Intervention Evaluation (EDIE-2) trial provides longitudinal data on sleep duration and individual psychotic experiences from a cohort of individuals at risk of psychosis, which this study utilises in an opportunistic secondary analysis. Shorter and more variable sleep was hypothesised to be associated with more severe psychotic experiences and lower psychological wellbeing. Mixed effect models were used to test sleep duration and range as predictors of individual psychotic experiences and psychological wellbeing over the 12-24 months (with assessments every 3 months) in 160 participants. Shorter sleep duration was associated with more severe delusional ideas and hallucinations cross-sectionally and longitudinally. The longitudinal relationships did not remain significant after conservative controls were added for the previous severity of psychotic experiences. No significant relationships were found between the sleep variables and other psychotic experiences (e.g. cognitive disorganisation), or psychological wellbeing. The results support a relationship between shorter sleep duration and delusional ideas and hallucinations. Future studies should focus on improving sleep disturbance measurement, and test whether treating sleep improves clinical trajectory in the at-risk group.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.