ArticleBiological psychiatry2018
Decreased Cannabinoid CB
Open access · greenAbstract read
In one paragraph
Article in Biological psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis.The lancet. Psychiatry · 2020Pooled it
- A multi-site study examining the tobacco withdrawal trajectory in people with tobacco and cannabis co-use.Drug and alcohol dependence · 2025Trial
- Brain imaging of cannabinoid type I (CBAddiction biology · 2021Trial
- Cannabinoid type 1 receptor availability imaging in attention-deficit/hyperactivity disorder using [EJNMMI reports · 2026Article
- PET Molecular Imaging of the Endocannabinoid System in Psychiatric Disorders.Neuroscience bulletin · 2026Review
- Effects of Progressive Aerobic Training on Executive-Reward Network Connectivity and Symptoms of Internet Gaming Disorder: Randomized Controlled Trial.JMIR serious games · 2025Article
- A Preliminary Investigation of Brain Cannabinoid Receptor Type 1 (CB1R) Availability in Men with Opioid Use Disorder.Research square · 2025Article
- A preliminary investigation of tobacco co-use on endocannabinoid activity in people with cannabis use.Drug and alcohol dependence reports · 2025Article
- Synthesis of New N,N'-Diarylureas and Their Theoretical Study as Cannabinoid-1 Receptor Inhibitors.ChemPlusChem · 2025Article
- Prenatal Cannabis and Tobacco Co-Exposure and Its Association with Behavioural Outcomes in Middle Childhood: Co-exposition prénatale au cannabis et au tabac et son association avec les résultats comportementaux au cours de l'enfance intermédiaire.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2025Article
- The endocannabinoid system as a putative target for the development of novel drugs for the treatment of psychiatric illnesses.Psychological medicine · 2023Review
- Review
- Cannabinoid Receptor Type 1 in Parkinson's Disease: A Positron Emission Tomography Study with [Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Molecular Alterations of the Endocannabinoid System in Psychiatric Disorders.International journal of molecular sciences · 2022Review
- Biomarkers of the Endocannabinoid System in Substance Use Disorders.Biomolecules · 2022Review
- The effects of fatty acid amide hydrolase inhibition and monoacylglycerol lipase inhibition on habit formation in mice.The European journal of neuroscience · 2022Article
- The neural and molecular basis of working memory function in psychosis: a multimodal PET-fMRI study.Molecular psychiatry · 2021Article
- Endocannabinoid system in psychotic and mood disorders, a review of human studies.Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- The CB1R rs2023239 receptor gene variant significantly affects the reinforcing effects of nicotine, but not cue reactivity, in human smokers.Brain and behavior · 2021Article
- Independent and Combined Effects of Nicotine or Chronic Tobacco Smoking and HIV on the Brain: A Review of Preclinical and Clinical Studies.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
Corrections and comments
- Commented on by
Authors and funding
11 authors at 4 institutions in 2 countries.
Jussi HirvonenMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; Department of Radiology, University of Turku, Turku, Finland. Electronic address: jussi.hirvonen@utu.fi.
Paolo Zanotti-FregonaraMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland; Houston Methodist Research Institute, Houston, Texas.
David A GorelickChemistry and Drug Metabolism Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland; Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, Maryland.
Chul Hyoung LyooMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Denise Rallis-FrutosMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Cheryl MorseMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Nora D VolkowOffice of the Director, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland.
Marilyn A HuestisChemistry and Drug Metabolism Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland; Lambert Center for the Study of Medicinal Cannabis and Hemp, Thomas Jefferson University, Philadelphia, Pennsylvania.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
National Institute of Mental Health · USNational Institutes of Health · USOffice of the Director · USThomas Jefferson University · US
Funding
Neurobiology of Substance Abuse and AddictionZIAAA000550 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI VOLKOW, NORA D. · 2009 to 2025
$115.1MPET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8MClinical Evaluation of PET RadiotracersZIAMH002852 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$48.6MSmoked Drugs Of Abuse: Pharmacokinetics/PharmacodynamicsZ01DA000413 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HUESTIS, MARILYN A · 1998 to 2008
$746kIntramural NIH HHS Z01 DA000413Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002852
Abstract
backgroundPrevious studies showed reduction of brain cannabinoid CB
methodsWe measured CB
resultsBrain CB
conclusionsTobacco-smoking healthy men have a widespread reduction of CB
Indexed as
AdultAllelesBrainCase-Control StudiesHumansMalePositron-Emission TomographyRadionuclide ImagingReceptor, Cannabinoid, CB1Tobacco Use DisorderYoung AdultCNR1 protein, humanReceptor, Cannabinoid, CB1AddictionBrain imagingCannabinoid CB(1) receptorPositron emission tomographySmokingTobacco
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.