Evidence map›Paper›PMID 30121090›Full record

Observational studyCritical care (London, England)2018

Investigation of microcirculation in patients with venoarterial extracorporeal membrane oxygenation life support.

Yu-Chang Yeh, Chen-Tse Lee, Chih-Hsien Wang, Yu-Kang Tu, Chien-Heng Lai, Yin-Chin Wang, Anne Chao, Chi-Hsiang Huang, Ya-Jung Cheng, Yih-Sharng Chen and 1 more

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02393274 (Investigation of Microcirculation in Patients With Venoarterial Extracorporeal Membrane Oxygenation Life Support), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02393274 completednot on this map

Investigation of Microcirculation in Patients With Venoarterial Extracorporeal Membrane Oxygenation Life Support

TypeobservationalSponsorNational Taiwan University HospitalRan2015 to 2016Enrolled48ConditionsHeart Failure, Respiratory FailureArmsExtra-corporeal membrane oxygenation life support
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  20. Hurdles to Cardioprotection in the Critically Ill.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yu-Chang YehDepartment of Anesthesiology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shang South Road, Taipei, Taiwan.
Chen-Tse LeeDepartment of Anesthesiology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shang South Road, Taipei, Taiwan.
Chih-Hsien WangDepartment of Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shang South Road, Taipei, Taiwan.
Yu-Kang TuDepartment of Public Health, Institute of Epidemiology & Preventive Medicine, National Taiwan University, No. 17, Xu-Zhou Road, Taipei, Taiwan.
Chien-Heng LaiDepartment of Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shang South Road, Taipei, Taiwan.
Yin-Chin WangDepartment of Anesthesiology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shang South Road, Taipei, Taiwan.
Anne ChaoDepartment of Anesthesiology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shang South Road, Taipei, Taiwan.
Chi-Hsiang HuangDepartment of Anesthesiology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shang South Road, Taipei, Taiwan.
Ya-Jung ChengDepartment of Anesthesiology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shang South Road, Taipei, Taiwan. chengyj@ntu.edu.tw.
Yih-Sharng ChenDepartment of Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, No 7, Chung Shang South Road, Taipei, Taiwan. yschen1234@gmail.com.
NTUH Center of Microcirculation Medical Research (NCMMR)
National Taiwan University Hospital · TWNational Taiwan University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 104 - 2314 - B - 002 - 045National Taiwan University Hospital NTUH 105-A125
6 · The paper itself

Abstract

backgroundMicrocirculatory dysfunction develops in both septic and cardiogenic shock patients, and it is associated with poor prognosis in patients with septic shock. Information on the association between microcirculatory dysfunction and prognosis in cardiogenic shock patients with venoarterial extracorporeal membrane oxygenation (VA-ECMO) support is limited.

methodsSublingual microcirculation images were recorded using an incident dark-field video microscope at the following time points: within 12 h (T1), 24 h (T2), 48 h (T3), 72 h (T4), and 96 h (T5) after VA-ECMO placement. If a patient could be weaned off VA-ECMO, sublingual microcirculation images were recorded before and after VA-ECMO removal. Microcirculatory parameters were compared between 28-day nonsurvivors and survivors with VA-ECMO support. In addition, the microcirculation and clinical parameters were assessed as prognostic tests of 28-day mortality, and patients were divided into three subgroups according to microcirculation parameters for survival analysis.

resultsForty-eight patients were enrolled in this study. At T1, the observed heart rate, mean arterial pressure, inotropic score and lactate level of 28-day nonsurvivors and survivors did not differ significantly, but the perfused small vessel density (PSVD) and proportion of perfused vessels (PPV) were lower in the 28-day nonsurvivors than in the survivors. The PSVD and PPV were slightly superior to lactate levels in predicting 28-day mortality (area under curve of 0.68, 0.70, and 0.62, respectively). The subgroup with the lowest PSVD (< 15 mm/mm

conclusionsEarly microcirculatory parameters could be used to predict the survival of cardiogenic shock patients with VA-ECMO support.

trial registrationClinicalTrials.gov, NCT02393274 . Registered on 19 March 2015.

Indexed as

AdultAgedAPACHEArea Under CurveChi-Square DistributionExtracorporeal Membrane OxygenationFemaleHumansMaleMicrocirculationMiddle AgedProspective StudiesROC CurveTaiwanCardiogenic shockExtracorporeal membrane oxygenationMicrocirculationSurvival

Identifiers

PMID30121090
PMCPMC6098836
OpenAlexW2887315361

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.