ArticleAlzheimer's research & therapy2018
Cerebrovascular disease influences functional and structural network connectivity in patients with amnestic mild cognitive impairment and Alzheimer's disease.
Article in Alzheimer's research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Neural correlates of subjective cognitive decline in Alzheimer's disease: a systematic review of structural and functional brain changes for early diagnosis and intervention.Frontiers in aging neuroscience · 2025Pooled it
- Retinal vessel diameter reflects altered resting-state fMRI connectivity and cognitive performance: A community-based study.GeroScience · 2026Article
- Lateralization Disruption and Dynamic Balance Alterations in Alzheimer's Disease: Impacts on Hemispheric Interaction and Cognitive Performance.Human brain mapping · 2025Article
- Hippocampal T1WI radiomics- and clinical feature-based models for predicting early mild cognitive impairment in secondary hydrocephalus.Frontiers in aging neuroscience · 2025Article
- The moderating role of information processing speed in the relationship between brain remodeling and episodic memory in amnestic mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Brain structure, amyloid, and behavioral features for predicting clinical progression in subjective cognitive decline.Human brain mapping · 2024Article
- Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke.PNAS nexus · 2024Article
- Small vessel disease burden and functional brain connectivity in mild cognitive impairment.Cerebral circulation - cognition and behavior · 2024Article
- Aberrant baseline brain activity and disrupted functional connectivity in patients with vascular cognitive impairment due to cerebral small vessel disease.Frontiers in neurology · 2024Article
- Associations of Blood Cardiovascular Biomarkers With Brain Free Water and Its Relationship to Cognitive Decline: A Diffusion-MRI Study.Neurology · 2023Article
- Deep phenotyping of Alzheimer's disease leveraging electronic medical records identifies sex-specific clinical associations.Nature communications · 2022Article
- Abnormal Dynamic Functional Networks in Subjective Cognitive Decline and Alzheimer's Disease.Frontiers in computational neuroscience · 2022Article
- Asymptomatic carotid stenosis is associated with both edge and network reconfigurations identified by single-subject cortical thickness networks.Frontiers in aging neuroscience · 2022Article
- Dementia in Southeast Asia: influence of onset-type, education, and cerebrovascular disease.Alzheimer's research & therapy · 2021Article
- The role of the medial prefrontal cortex in cognition, ageing and dementia.Brain communications · 2021Review
- Observational
- The Influence of Cerebral Small Vessel Disease on Static and Dynamic Functional Network Connectivity in Subjects Along Alzheimer's Disease Continuum.Brain connectivity · 2021Article
- Effects of gut microbiota and probiotics on Alzheimer's disease.Translational neuroscience · 2021Review
- Perspectives on mild cognitive impairment as a precursor of Alzheimer's disease.Neural regeneration research · 2020Review
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPatients with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) show functional and structural connectivity alterations in the default mode network (DMN) while cerebrovascular disease (CeVD) shows functional and structural connectivity changes in the executive control network (ECN). Such disruptions are associated with memory and executive function impairment, respectively. Concurrent AD and CeVD pathology is associated with a higher rate of cognitive decline and differential neurodegenerative patterns. Together, such findings are likely reflective of different underlying pathology in AD with and without CeVD. However, few studies have examined the effect of CeVD on network functional connectivity (task-free functional magnetic resonance imaging (fMRI)) and structural connectivity (diffusion MRI) of the DMN and ECN in aMCI and AD using a hypothesis-driven multiple seed-based approach.
methodsWe examined functional and structural connectivity network changes in 39 aMCI, 50 aMCI+CeVD, 47 AD, 47 AD+CeVD, and 65 healthy controls (HCs) and their associations with cognitive impairment in the executive/attention and memory domains.
resultsWe demonstrate divergent DMN and ECN functional connectivity changes in CeVD and non-CeVD subjects. Compared with controls, intra-DMN hippocampal functional connectivity reductions were observed in both AD and AD+CeVD, while intra-DMN parietal and medial prefrontal-parietal functional connectivity was higher in AD+CeVD and aMCI+CeVD, but lower in AD. Intra-ECN frontal functional connectivity increases and fronto-parietal functional connectivity decreases occurred in CeVD but not non-CeVD subjects. Such functional connectivity alterations were related with cognitive impairment in a dissociative manner: intra-DMN functional connectivity changes were associated with worse cognition primarily in non-CeVD groups, while intra-ECN functional connectivity changes were associated with worse cognition primarily in CeVD groups. Additionally, CeVD and non-CeVD groups showed overlapping and distinct alterations in inter-network DMN-ECN functional connectivity depending on disease severity. In contrast to functional connectivity, CeVD groups had greater network structural connectivity damage compared with non-CeVD groups in both aMCI and AD patients. Network structural connectivity damage was associated with worse cognition.
conclusionsWe demonstrate differential functional and structural network changes between aMCI and AD patients with and without CeVD through diverging and deleterious network-based degeneration underlying domain-specific cognitive impairment.
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