ArticleBMC musculoskeletal disorders2018
Descriptive epidemiology and outcomes of bone sarcomas in adolescent and young adult patients in Japan.
Article in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Prognostic Factors in Newly Diagnosed High-Grade Osteosarcoma-A Systematic Review.Cancer medicine · 2025Pooled it
- Evaluation of limb function after treatment with chemotherapy and carbon ion radiotherapy for Ewing sarcoma of the scapula: A report of three cases.Oncology letters · 2026Article
- Article
- Epidemiology and Prognosis of Patients With Osteosarcoma at Different Primary Sites: A SEER Population-Based Study.Cancer reports (Hoboken, N.J.) · 2026Article
- Interval-compressed chemotherapy in patients with Ewing's sarcoma: report on feasibility and toxicity from a North African center.Frontiers in oncology · 2026Article
- Unveiling trends in malignant neoplasms of bone and articular cartilage mortality in the United States (1999-2023): a CDC WONDER perspective.Frontiers in oncology · 2026Article
- Review
- Use of Period Analysis to Timely Assess Five-Year Relative Survival for the Patients With Bone Cancer.World journal of oncology · 2024Article
- Amputation surgery associated with shortened survival in patients with localized extremity bone sarcoma.Journal of orthopaedics · 2024Article
- Multiple myeloma in a young female presenting as an aggressive skull-base tumour.SA journal of radiology · 2024Article
- A short-term three dimensional culture-based drug sensitivity test is feasible for malignant bone tumors.Human cell · 2023Article
- Massage manipulation and progression of osteosarcoma, does it really correlate: a combination of prospective and retrospective cohort study.Scientific reports · 2023Observational
- Epidemiology of pediatric sarcoma in Iran.Cancer reports (Hoboken, N.J.) · 2023Article
- Clinical Characteristics and Prognostic Risk Factors of Parasellar Chondrosarcoma.Brain sciences · 2022Article
- Incidence Patterns and Outcomes of Ewing Sarcoma in South Korea (1999-2017): A Retrospective Analysis Using Korea Central Cancer Registry Data.Cancer research and treatment · 2022Article
- Challenges of Systemic Therapy Investigations for Bone Sarcomas.International journal of molecular sciences · 2022Review
- Incidence of primary bone sarcomas in Iranian population (2008-2015): A national population-based study.Caspian journal of internal medicine · 2022Article
- Patterns and Trends of the Mortality From Bone Cancer in Pudong, Shanghai: A Population-Based Study.Frontiers in oncology · 2022Article
- Osteosarcoma in Adolescents and Young Adults.Cells · 2021Article
- Homogenous and Heterogenous Prognostic Factors for Patients with Bone Sarcoma.Orthopaedic surgery · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere have been fewer improvements in the clinical outcomes of adolescent and young adult (AYA) patients with cancer than for children and older adults, possibly because fewer studies focus on patients in this age group. The aims of this study were (1) to determine survival rates of bone sarcoma among AYAs in Japan (for comparison with other age groups), and (2) to establish whether belonging to the AYA age group at diagnosis was correlated with poor cancer survival in Japan.
methodsA total of 3457 patients diagnosed with bone sarcoma (1930 male and 1527 female) were identified from 63,931 records in the Bone and Soft Tissue Tumor (BSTT) registry, a nationwide Japanese database, from 2006 to 2013. The histologic subtypes of bone sarcoma were osteosarcoma, chondrosarcoma, and Ewing sarcoma. The primary endpoints for prognosis were the occurrence of tumor-related death. We compared the epidemiological features of AYAs with other age groups. The cancer survival rates were calculated using the Kaplan-Meier method. Cox proportional hazards models were used to analyze the prognostic factors for cancer survival.
resultsThe majority of AYA had osteosarcoma 631 (56.2%), while 198 (17.6%) had chondrosarcoma. The frequency of bone sarcoma occurrence was highest among AYA patients, who accounted for a marked proportion of patients with each type of sarcoma. With the exception of sarcoma type, AYA patients did not significantly differ from patients in other age groups for any of the investigated clinicopathological parameters. Cancer survival of AYA patients was significantly higher than in the elderly. Univariate and multivariate analyses revealed that AYA status was not a predictor of poor cancer survival. However, older age (≥65 years) was a predictor of poor cancer survival in patients with overall bone sarcoma, osteosarcoma, chondrosarcoma.
conclusionThis epidemiological study is the first to investigate AYA patients with bone sarcoma using the nationwide BSTT Registry. We found that cancer survival of AYA patients was significantly higher than that of the elderly. AYA status was not a predictor of poor cancer survival in Japan.
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