Evidence map›Paper›PMID 30121083›Full record

Observational studyCritical care (London, England)2018

Predictors of insufficient peak amikacin concentration in critically ill patients on extracorporeal membrane oxygenation.

Cyril Touchard, Alexandra Aubry, Philippine Eloy, Nicolas Bréchot, Guillaume Lebreton, Guillaume Franchineau, Sebastien Besset, Guillaume Hékimian, Ania Nieszkowska, Pascal Leprince and 3 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Cyril TouchardMedical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Alexandra AubryLaboratory of Microbiology, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Philippine EloyDepartment of Epidemiology, Biostatistics and Clinical Research, Bichat Hospital, AP-HP, F-75018, Paris, France.
Nicolas BréchotMedical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Guillaume LebretonCardiac Surgery Department, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Guillaume FranchineauMedical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Sebastien BessetMedical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Guillaume HékimianMedical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Ania NieszkowskaMedical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Pascal LeprinceCardiac Surgery Department, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Charles-Edouard LuytMedical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Alain CombesMedical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France.
Matthieu SchmidtMedical Intensive Care Unit, iCAN, Institute of Cardiometabolism and Nutrition, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University , Paris 6, 47, bd de l'Hôpital, 75651, Paris Cedex 13, France. matthieuschmidt@yahoo.fr.
Pitié-Salpêtrière Hospital · FRFondation pour l’innovation en Cadiométabolisme et Nutrition · FRAssistance Publique – Hôpitaux de Paris · FRSorbonne Université · FRHôpital Bichat-Claude-Bernard · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmikacin infusion requires targeting a peak serum concentration (C

methodsThis was a prospective, observational, monocentric study in a university hospital. Patients on ECMO who received an amikacin loading dose for suspected Gram-negative infections were included. The amikacin loading dose of 25 mg/kg total body weight was administered intravenously and C

resultsA total of 106 patients on venoarterial ECMO (VA-ECMO) (68%) or venovenous-ECMO (32%) were included. At inclusion, their median (1st; 3rd quartile) Sequential Organ-Failure Assessment score was 15 (12; 18) and 54 patients (51%) were on renal replacement therapy. Overall ICU mortality was 54%. C

conclusionsECMO-treated patients were under-dosed for amikacin in one third of cases. Increasing the dose to 35 mg/kg of body weight in low-BMI patients and those with positive 24-h fluid balance on ECMO to reach adequate targeted concentrations should be investigated.

Indexed as

Dose-Response Relationship, DrugAdultAmikacinCohort StudiesCritical IllnessExtracorporeal Membrane OxygenationFemaleHumansInfusion PumpsInfusions, IntravenousMaleMiddle AgedProspective StudiesAmikacinAcute respiratory distress syndromeAmikacinCardiac failurePharmacokineticsShockVolume of distribution

Identifiers

PMID30121083
PMCPMC6098833
OpenAlexW2885081166

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.