ArticleNeural development2018
Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation.
Article in Neural development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 28 citations in OpenAlex.
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- Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia.bioRxiv : the preprint server for biology · 2024Article
- Orexin-A increases the differentiation of human olfactory sensory neurons through orexin receptor type 1.Regenerative therapy · 2024Article
- Piezo1-mediated spontaneous calcium transients in satellite glia impact dorsal root ganglia development.PLoS biology · 2023Article
- Evolutionarily conserved concepts in glial cell biology.Current opinion in neurobiology · 2023Review
- Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord injury.Frontiers in molecular neuroscience · 2023Article
- The embryonic zebrafish brain is seeded by a lymphatic-dependent population of mrc1Nature neuroscience · 2022Article
- A Subset of Oligodendrocyte Lineage Cells Interact With the Developing Dorsal Root Entry Zone During Its Genesis.Frontiers in cellular neuroscience · 2022Article
- Quantifying Glial-Glial Tiling Using Automated Image Analysis inFrontiers in cellular neuroscience · 2022Article
- Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function.PLoS biology · 2021 · on this mapArticle
- Met is required for oligodendrocyte progenitor cell migration in Danio rerio.G3 (Bethesda, Md.) · 2021Article
- Article
- Tetris in the Nervous System: What Principles of Neuronal Tiling Can Tell Us About How Glia Play the Game.Frontiers in cellular neuroscience · 2021Review
- Pioneer axons employ Cajal's battering ram to enter the spinal cord.Nature communications · 2019Article
- Microglia exit the CNS in spinal root avulsion.PLoS biology · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlial cell ensheathment of specific components of neuronal circuits is essential for nervous system function. Although ensheathment of axonal segments of differentiated neurons has been investigated, ensheathment of neuronal cell somas, especially during early development when neurons are extending processes and progenitor populations are expanding, is still largely unknown.
methodsTo address this, we used time-lapse imaging in zebrafish during the initial formation of the dorsal root ganglia (DRG).
resultsOur results show that DRG neurons are ensheathed throughout their entire lifespan by a progenitor population. These ensheathing cells dynamically remodel during development to ensure axons can extend away from the neuronal cell soma into the CNS and out to the skin. As a population, ensheathing cells tile each DRG neuron to ensure neurons are tightly encased. In development and in experimental cell ablation paradigms, the oval shape of DRG neurons dynamically changes during partial unensheathment. During longer extended unensheathment neuronal soma shifting is observed. We further show the intimate relationship of these ensheathing cells with the neurons leads to immediate and choreographed responses to distal axonal damage to the neuron.
conclusionWe propose that the ensheathing cells dynamically contribute to the shape and position of neurons in the DRG by their remodeling activity during development and are primed to dynamically respond to injury of the neuron.
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