Evidence map›Paper›PMID 30120721›Full record

ArticleHead and neck pathology2019

Identifying Candidate Biomarkers for Pleomorphic Adenoma: A Case-Control Study.

Matthew D Morrison, Linda Jackson-Boeters, Zia A Khan, Michael S Shimizu, Jason H Franklin, Kevin Fung, John H J Yoo, Mark R Darling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew D MorrisonDivision of Oral and Maxillofacial Surgery, Department of Dentistry, London Health Sciences Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada. matthew.morrison@londonhospitals.ca.
Linda Jackson-BoetersDepartment of Pathology and Laboratory Medicine, University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5C1, Canada.
Zia A KhanDepartment of Pathology and Laboratory Medicine, University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5C1, Canada.
Michael S ShimizuDivision of Oral and Maxillofacial Surgery, Department of Dentistry, London Health Sciences Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
Jason H FranklinDivision of Head and Neck Oncology and Reconstructive Surgery, Department of Otolaryngology, Kingston Health Sciences Centre, 144 Brock Street, Kingston, ON, K7L 5G2, Canada.
Kevin FungDivision of Head and Neck Oncology and Reconstructive Surgery, Department of Otolaryngology, London Health Sciences Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
John H J YooDivision of Head and Neck Oncology and Reconstructive Surgery, Department of Otolaryngology, London Health Sciences Centre, 339 Windermere Road, London, ON, N6A 5A5, Canada.
Mark R DarlingDivision of Oral and Maxillofacial Pathology, Department of Pathology and Laboratory Medicine, University of Western Ontario, 1151 Richmond Street, London, ON, N6A 5C1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Kallikrein-related peptidases have been identified as biomarkers in many human tumors and may influence tumor behavior. We investigated KLK1-15 messenger ribonucleic acid and proteins in PA specimens to determine a KLK expression profile for this tumor. Fresh frozen PA tissue specimens (n = 26) and matched controls were subjected to quantitative real-time reverse transcription polymerase chain reaction to detect KLK1-15 mRNA. Expression of KLK1, KLK12, KLK13, and KLK8 proteins were then evaluated via immunostaining techniques. Statistical analyses were performed with the level of significance set at P < .05. We observed downregulation of KLK1, KLK12, and KLK13 mRNA expression, and immunostaining studies revealed downregulation of the corresponding proteins. Histologic evidence of capsular perforation was associated with increased KLK1 protein expression. Tumor size was not associated with capsular invasion and/or perforation. This study is the first to detail a KLK expression profile for PA at both the transcriptional level and the protein level. Future work is required to develop clinical applications of these findings.

Indexed as

Adenoma, PleomorphicAdultAgedAged, 80 and overBiomarkers, TumorCase-Control StudiesFemaleHumansKallikreinsMaleMiddle AgedSalivary Gland NeoplasmsBiomarkers, TumorKallikreinsBiomarkersImmunohistochemistryKallikrein-related peptidasesKallikreinsPleomorphic adenomaSalivary gland tumors

Identifiers

PMID30120721
PMCPMC6684674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.