ReviewMolecular imaging and biology2018
Metabolic and Molecular Imaging with Hyperpolarised Tracers.
Review in Molecular imaging and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Article
- Article
- Imaging drug delivery to the lungs: Methods and applications in oncology.Advanced drug delivery reviews · 2023Review
- Catalyst-Free Aqueous Hyperpolarized [1-ACS sensors · 2022Article
- Hyperpolarized [1-Molecular imaging and biology · 2022Article
- SABRE hyperpolarized anticancer agents for use inMagnetic resonance in medicine · 2022Article
- Rapid SABRE Catalyst Scavenging Using Functionalized Silicas.Molecules (Basel, Switzerland) · 2022Article
- ParaHydrogen Polarized Ethyl-[1-Chemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- HyperpolarizedNMR in biomedicine · 2021Review
- Oncometabolites in renal cancer.Nature reviews. Nephrology · 2020Review
- Hyperpolarization of Pyridyl Fentalogues by Signal Amplification By Reversible Exchange (SABRE).ChemistryOpen · 2019Article
- Multiple Quantum Coherences Hyperpolarized at Ultra-Low Fields.Chemphyschem : a European journal of chemical physics and physical chemistry · 2019Article
- The beginning of the end for conventional RECIST - novel therapies require novel imaging approaches.Nature reviews. Clinical oncology · 2019Review
- Parahydrogen-Induced Polarization of 1-The journal of physical chemistry. C, Nanomaterials and interfaces · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Since reaching the clinic, magnetic resonance imaging (MRI) has become an irreplaceable radiological tool because of the macroscopic information it provides across almost all organs and soft tissues within the human body, all without the need for ionising radiation. The sensitivity of MR, however, is too low to take full advantage of the rich chemical information contained in the MR signal. Hyperpolarisation techniques have recently emerged as methods to overcome the sensitivity limitations by enhancing the MR signal by many orders of magnitude compared to the thermal equilibrium, enabling a new class of metabolic and molecular X-nuclei based MR tracers capable of reporting on metabolic processes at the cellular level. These hyperpolarised (HP) tracers have the potential to elucidate the complex metabolic processes of many organs and pathologies, with studies so far focusing on the fields of oncology and cardiology. This review presents an overview of hyperpolarisation techniques that appear most promising for clinical use today, such as dissolution dynamic nuclear polarisation (d-DNP), parahydrogen-induced hyperpolarisation (PHIP), Brute force hyperpolarisation and spin-exchange optical pumping (SEOP), before discussing methods for tracer detection, emerging metabolic tracers and applications and progress in preclinical and clinical application.
Indexed as
Identifiers
30120644What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.