ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019
Stability of symptom clusters and sentinel symptoms during the first two cycles of adjuvant chemotherapy.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The Effectiveness of Interventions Based on Symptom Clusters for Symptom Burden and Quality of Life Among Cancer Patients: A Meta-Analysis of Randomized Controlled Trials.Research in nursing & health · 2026Pooled it
- Research advances in exercise and cognitive fatigue: a bibliometric analysis and thematic strategic evolution analysis.Frontiers in psychology · 2026Pooled it
- Exploring Symptom Cluster Patterns in Adult Cancer Patients Undergoing Chemotherapy: A Systematic Review.Journal of Korean Academy of Nursing · 2024Pooled it
- Investigating the symptoms and sentinel symptoms of patients with lymphoma during chemotherapy: a cross-sectional survey.BMJ open · 2025Article
- Symptom clusters and their influencing factors among Vietnamese women after cancer treatment.Scientific reports · 2025Article
- Symptom network analysis during radiotherapy in gastrointestinal cancers: A longitudinal study primarily involving esophageal cancer patients.Asia-Pacific journal of oncology nursing · 2025Article
- Symptom clusters and sentinel symptoms during post-transplant recovery in recipients of allogeneic hematopoietic stem cell transplantation: A cross-sectional study.Asia-Pacific journal of oncology nursing · 2025Article
- Medical and psychosocial symptom clusters and their temporal patterns in people with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Immersive virtual nature for improving psychological distress of breast cancer patients undergoing intravenous chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Symptom Network Analysis in Patients Undergoing Chemotherapy for Colorectal Cancer: A Cross-Sectional Study.Cancer management and research · 2025Article
- Identification of symptom clusters and sentinel symptoms during the first cycle of chemotherapy in patients with lung cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Identifying symptom clusters and temporal interconnections in patients with lung tumors after CT-guided microwave ablation: A network analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- A longitudinal study of symptom cluster latent profiles in ovarian cancer patients undergoing chemotherapy.Cancer medicine · 2024Article
- Symptom clusters in oncology outpatients: stability and consistency across a cycle of chemotherapy.BMJ supportive & palliative care · 2024Article
- Advanced statistics identification of participant and treatment predictors associated with severe adverse effects induced by fluoropyrimidine-based chemotherapy.Cancer chemotherapy and pharmacology · 2023Article
- Contemporaneous symptom networks of multidimensional symptom experiences in cancer survivors: A network analysis.Cancer medicine · 2023Article
- Knowledge, attitudes and behaviors toward healthy eating among Chinese cancer patients treated with chemotherapy: A systematic review.Asia-Pacific journal of oncology nursing · 2023Review
- Network analysis to identify symptoms clusters and temporal interconnections in oncology patients.Scientific reports · 2022Article
- Symptom clusters and quality of life in ambulatory patients with multiple myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Symptom clusters in patients with colorectal cancer after colostomy: a longitudinal study in Shanghai.The Journal of international medical research · 2021Observational
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
purposeAscertaining the stability of symptom clusters and identifying sentinel symptoms have been top priorities in symptom cluster research. Identifying sentinel symptoms would help to determine the underlying mechanisms of symptom clusters and facilitate effective symptom management. This study aimed to evaluate the stability of symptom clusters during the 1st and 2nd cycles of adjuvant chemotherapy (CTx) and to identify sentinel symptoms.
methodsThis is a secondary data analysis of data from the Paradigm Shift in Chemotherapy-Induced Nausea and Vomiting (PS-CINV) study. Data utilized were from cancer patients who received adjuvant chemotherapy and completed symptom evaluation in the 1st and 2nd cycles (N = 209). The severity of 20 symptoms was evaluated on a 0-to-10 numeric rating scale. Principal component and hierarchical cluster analyses identified symptom clusters, and principal variable analysis identified sentinel symptoms.
resultsAmong 20 symptoms, 13 symptoms formed 4 symptom clusters in the 1st cycle: a physical-psychological (pain, dyspnea, sleep disturbance, anxiety, depression), a gastrointestinal (nausea, loss of appetite, taste change), a fatigue-cognitive (fatigue, difficulty concentrating, drowsiness), and a urosexual (urinary problem, sexual problem) symptom cluster. During the 2nd cycle, stable symptom clusters were identified, with merging of the physical-psychological and fatigue-cognitive symptom clusters, resulting in three clusters. Sentinel symptoms were identified in the following order: anxiety, loss of appetite and fatigue (1st cycle) and loss of appetite, depression, and fatigue (2nd cycle).
conclusionSymptom clusters demonstrated phase-specific stability. The current study identified a core set of symptoms that form stable symptom clusters during the 1st and 2nd cycles of CTx. Principal variable analysis identified sentinel symptoms which could facilitate efficient symptom management.
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