Evidence map›Paper›PMID 30120534›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2019

Psychiatric comorbidity as a risk factor for mortality in people with anorexia nervosa.

Hubertus Himmerich, Matthew Hotopf, Hitesh Shetty, Ulrike Schmidt, Janet Treasure, Richard D Hayes, Robert Stewart, Chin-Kuo Chang

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PubMed Publisher
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. The Efficacy of Pharmacological Treatment of Depression in Anorexia Nervosa and Underweight Patients: A Systematic Review.European eating disorders review : the journal of the Eating Disorders Association · 2026
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  17. Mortality and care of eating disorders.Acta psychiatrica Scandinavica · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Hubertus HimmerichDepartment of Psychological Medicine, King's College London, London, UK.
Matthew HotopfDepartment of Psychological Medicine, King's College London, London, UK.
Hitesh ShettySouth London and Maudsley NHS Foundation Trust, London, UK.
Ulrike SchmidtDepartment of Psychological Medicine, King's College London, London, UK.
Janet TreasureDepartment of Psychological Medicine, King's College London, London, UK.
Richard D HayesDepartment of Psychological Medicine, King's College London, London, UK.
Robert StewartDepartment of Psychological Medicine, King's College London, London, UK.
Chin-Kuo ChangDepartment of Psychological Medicine, King's College London, London, UK. ckchang@utaipei.edu.tw.ORCID http://orcid.org/0000-0002-8338-7196
King's College London · GBSouth London and Maudsley NHS Foundation Trust · GB

Funding

Medical Research Council MC_PC_17214
6 · The paper itself

Abstract

Anorexia nervosa (AN) is found associated with increased mortality. Frequent comorbidities of AN include substance use disorders (SUD), affective disorders (AD) and personality disorders (PD). We investigated the influence of these psychiatric comorbidities on all-cause mortality with demographic and socioeconomic factors considered as confounders in the observation window between January 2007 and March 2016 for 1970 people with AN, using data from the case register of the South London and Maudsley (SLaM) NHS Foundation Trust, an almost monopoly-secondary mental healthcare service provider in southeast London. We retrieved data from its Clinical Records Interactive Search (CRIS) system as data source. Mortality was ascertained through nationwide tracing by the UK Office for National Statistics (ONS) linked to CRIS database on a monthly basis. A total of 43 people with AN died during the observation period. Standardized Mortality Ratio (SMR) with England and Wales population in 2012 as standard population for our study cohort was 5.21 (95% CI 3.77, 7.02). In univariate analyses, the comorbidity of SUD or PD was found to significantly increase the relative risks of mortality (HRs = 3.10, 95% CI 1.21, 7.92; and 2.58, 95% CI 1.23, 5.40, respectively). After adjustment for demographic and socioeconomic covariates as confounders, moderately but not significantly elevated risks were identified for SUD (adjusted HR = 1.39, 95% CI 0.53, 3.65) and PD (adjusted HR = 1.58, 95% CI 0.70, 3.56). These results suggest an elevated mortality in people with AN, which might be, at least partially, explained by the existence of the comorbidities SUD or PD.

Indexed as

AdolescentAdultAgedAged, 80 and overAnorexia NervosaChildChild, PreschoolComorbidityFemaleHumansMaleMiddle AgedMood DisordersPersonality DisordersRegistriesRetrospective StudiesAffective disorderAnorexia nervosaComorbiditiesPersonality disorderSubstance use disorder

Identifiers

PMID30120534
OpenAlexW2885442652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.