Evidence map›Paper›PMID 30120428›Full record

ArticleInternational journal of obesity (2005)2018

Predictive utility of childhood anthropometric measures on adult glucose homeostasis measures: a 20-year cohort study.

Feitong Wu, Valentina Ho, Brooklyn J Fraser, Michael D Schmidt, Terence Dwyer, Alison J Venn, Costan G Magnussen

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Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Feitong WuMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Valentina HoMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Brooklyn J FraserMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Michael D SchmidtDepartment of Kinesiology, University of Georgia College of Education, Athens, USA.
Terence DwyerMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Alison J VennMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Costan G MagnussenMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia. cmagnuss@utas.edu.au.ORCID http://orcid.org/0000-0002-6238-5730

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesChildhood body mass index (BMI) predicts adult glucose homeostasis measures and type 2 diabetes mellitus, but little is known about the predictive utility of other anthropometric measures in childhood. We aimed to identify the anthropometric measure in childhood that best predicts adult glucose homeostasis measures and examine if the combination of additional anthropometric measures further improves predictive utility.

methodsA 20-year follow-up of children participating in the Childhood Determinants of Adult Health Study (n = 2345, aged 7-15 years at baseline). Baseline anthropometric measures were waist circumference (WC), WC adjusted for height, weight adjusted for height, hip circumference, waist-hip-ratio, waist-height-ratio, BMI, conicity index, abdominal volume index (AVI), body adiposity index, and a body shape index. Fasting glucose and insulin levels measured at follow-up were used to define insulin resistance (HOMA2-IR), low beta-cell function (HOMA2-β), high fasting insulin, and impaired fasting glucose (IFG).

resultsAll child anthropometric measures were significantly associated with HOMA2-IR, HOMA2-β, and high fasting insulin (relative risk = 1.12-1.55), but not IFG. AVI had the largest area under receiver-operating curve (AUC) in predicting adult HOMA2-IR (AUC, 95% confidence interval: 0.610, 0.584-0.637), HOMA2-β (0.615, 0.588-0.642) and high fasting insulin (0.613, 0.587-0.639). Combining each additional anthropometric measure with AVI did not appreciably increase predictive utility (an increase of 0.001-0.002 in AUC, p > 0.05 for all).

conclusionsAnthropometric measures from a single time-point in childhood are associated with insulin-related outcomes 20-year later in adulthood. However, overall predictive utility was low and was not substantially enhanced by combining multiple different child anthropometric measures.

Indexed as

AdiposityAdultAustraliaBlood GlucoseBody Mass IndexCohort StudiesDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHomeostasisHumansInsulin ResistanceMalePredictive Value of TestsRisk FactorsROC CurveBlood Glucose

Identifiers

PMID30120428

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.