Evidence map›Paper›PMID 30120404›Full record

ArticlePediatric research2018

In a pilot study, reduced fatty acid desaturase 1 function was associated with nonalcoholic fatty liver disease and response to treatment in children.

Valerio Nobili, Anna Alisi, Zhipeng Liu, Tiebing Liang, Annalisa Crudele, Massimiliano Raponi, Jingmei Lin, Naga P Chalasani, Wanqing Liu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. From Transcriptional Reprogramming to Fat Quality Improvement: DietaryAnimals : an open access journal from MDPI · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Valerio NobiliDepartment of Pediatrics, University "La Sapienza", Rome, Italy. nobili66@yahoo.it.
Anna AlisiResearch Unit of Molecular Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Zhipeng LiuDepartment of Medicinal Chemistry, College of Pharmacy, Purdue University, West Lafayette, IN, USA.
Tiebing LiangDivision of Gastroenterology and Hepatology, Indiana Fatty Liver Disease Research Group, Indiana University School of Medicine, Indianapolis, IN, USA.
Annalisa CrudeleResearch Unit of Molecular Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Massimiliano RaponiMedical Directorate, Bambino Gesù Children's Hospital-IRCCS, Rome, Italy.
Jingmei LinDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Naga P ChalasaniDivision of Gastroenterology and Hepatology, Indiana Fatty Liver Disease Research Group, Indiana University School of Medicine, Indianapolis, IN, USA.
Wanqing LiuDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI, USA. wliu@wayne.edu.
Indiana University – Purdue University Indianapolis · USBambino Gesù Children's Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITPurdue University West Lafayette · USSapienza University of Rome · ITWayne State University · US

Funding

Fatty Acid Desaturase 1 (FADS1) Variants and Non-alcoholic Fatty Liver DiseaseR01DK106540 · NIDDK · WAYNE STATE UNIVERSITY · PI LIU, WANQING · 2016 to 2020
$1.9M
NIDDK NIH HHS R01 DK106540
6 · The paper itself

Abstract

backgroundFADS1 gene encodes delta 5 desaturase, a rate-limiting enzyme in the metabolism of n-3 and n-6 polyunsaturated fatty acids (PUFAs). Minor alleles of FADS1 locus polymorphisms are associated with reduced FADS1 expression and intra-hepatic fat accumulation. However, the relationship between FADS1 expression and pediatric nonalcoholic fatty liver disease (NAFLD) risk remains to be explored.

methodsWe analyzed FADS1 transcription levels and their association with intra-hepatic fat and histology in children, and we performed pathway enrichment analysis on transcriptomic profiles associated with FADS1 polymorphisms. We also evaluated the weight of FADS1 alleles on the response to combined docosahexaenoic acid, choline, and vitamin E (DHA-CHO-VE) treatment.

resultsFADS1 mRNA level was significantly and inversely associated with intra-hepatic fat (p = 0.004), degree of steatosis (p = 0.03), fibrosis (p = 0.05), and NASH (p = 0.008) among pediatric livers. Transcriptomics demonstrated a significant enrichment of a number of pathways strongly related to NAFLD (e.g., liver damage, fibrosis, and hepatic stellate cell activation). Compared to children who are common allele homozygotes, children with FADS1 minor alleles had a greater reduction in steatosis, fibrosis, and NAFLD activity score after DHA-CHO-VE.

conclusionThis study suggests that decreased FADS1 expression may be associated with NAFLD in children but an increased response to DHA-CHO-VE.

Indexed as

AdolescentAllelesChildChild, PreschoolDelta-5 Fatty Acid DesaturaseDocosahexaenoic AcidsFatty Acid DesaturasesFemaleHumansInfantInfant, NewbornLiverMaleNon-alcoholic Fatty Liver DiseasePilot ProjectsPolymorphism, GeneticDelta-5 Fatty Acid DesaturaseDocosahexaenoic AcidsFADS1 protein, humanFatty Acid DesaturasesRNA, Messenger

Identifiers

PMID30120404
PMCPMC6726123
OpenAlexW2885037127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.