ArticleNature chemical biology2018
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.
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Article in Nature chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
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Who cites it
40 citing papers in PubMed, 67 citations in OpenAlex.
- Arrestins as programmable integrators of GPCR signaling: structural microstates, spatiotemporal logic, and therapeutic control.Cell discovery · 2026Review
- Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.Nature communications · 2026Article
- GPCR Phospho-Barcodes and Biased Signaling.Handbook of experimental pharmacology · 2026Review
- Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.bioRxiv : the preprint server for biology · 2025Article
- G protein-coupled receptors: pivotal hubs in gastric cancer malignancy-from multidimensional crosstalk to precision therapeutics.Journal of translational medicine · 2025Review
- Genetic Code Expansion: Recent Developments and Emerging Applications.Chemical reviews · 2025Review
- β-arrestins Are Scaffolding Proteins Required for Shh-Mediated Axon Guidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Beneath the surface: endosomal GPCR signaling.Trends in biochemical sciences · 2024Review
- Distinct activation mechanisms of β-arrestin-1 revealed byNature communications · 2023Article
- Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome.Frontiers in immunology · 2023Review
- Exploring the diversity of AVPR2 in Primates and its evolutionary implications.Genetics and molecular biology · 2023Article
- Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling.eLife · 2022Article
- G-Protein Coupled Receptors in Human Sperm: An In Silico Approach to Identify Potential Modulatory Targets.Molecules (Basel, Switzerland) · 2022Article
- G protein-coupled receptor signaling: transducers and effectors.American journal of physiology. Cell physiology · 2022Review
- Serodolin, a β-arrestin-biased ligand of 5-HTProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- QR code model: a new possibility for GPCR phosphorylation recognition.Cell communication and signaling : CCS · 2022Review
- Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
21 authors at 5 institutions in 3 countries.
Fan YangKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Peng XiaoKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Chang-Xiu QuKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Qi LiuKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Liu-Yang WangDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA.
Zhi-Xin LiuKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Qing-Tao HeKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Chuan LiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.
Jian-Ye XuKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Rui-Rui LiKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Meng-Jing LiKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Qing LiKey Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, Shandong University School of Medicine, Shandong, China.
Xu-Zhen GuoInstitute of Biophysics, Chinese Academy of Sciences, Beijing, Chaoyang district, Beijing, China.
Zhao-Ya YangKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Dong-Fang HeKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China.
Fan YiDepartment of Pharmacology, Shandong University School of Medicine, Jinan, China.
Ke RuanLaboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei Anhui, China.
Yue-Mao ShenDepartment of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA.
Xiao YuKey Laboratory Experimental Teratology of the Ministry of Education and Department of Physiology, Shandong University School of Medicine, Shandong, China.
Jin-Peng SunKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, Shandong, China. sunjinpeng@sdu.edu.cn.ORCID http://orcid.org/0000-0003-3572-1580
Jiangyun WangInstitute of Biophysics, Chinese Academy of Sciences, Beijing, Chaoyang district, Beijing, China. jwang@ibp.ac.cn.
Shandong University · CNChinese Academy of Sciences · CNDuke University · USPeking University · CNUniversity of Science and Technology of China · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signals from 800 G-protein-coupled receptors (GPCRs) to many SH3 domain-containing proteins (SH3-CPs) regulate important physiological functions. These GPCRs may share a common pathway by signaling to SH3-CPs via agonist-dependent arrestin recruitment rather than through direct interactions. In the present study,
Indexed as
Allosteric RegulationSignal Transductionsrc Homology DomainsArrestinCells, CulturedHEK293 CellsHumansReceptors, G-Protein-CoupledArrestinReceptors, G-Protein-Coupled
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.