ArticleScientific reports2018
Detoxification mechanisms involved in ivermectin resistance in the cattle tick, Rhipicephalus (Boophilus) microplus.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients.BMC infectious diseases · 2021Trial
- Synergistic action of piperonyl butoxide with macrocyclic lactones in Rhipicephalus microplus.Experimental & applied acarology · 2026Article
- In vitro acaricide efficacy evaluation onParasite epidemiology and control · 2026Article
- Toxicity of ivermectin on multiple insecticide-resistant populations of Anopheles gambiae sensu lato, Aedes aegypti, and Culex mosquitoes.Parasites & vectors · 2026Article
- Acaricide resistance inFrontiers in veterinary science · 2026Article
- Acaricidal bioactivity and molecular target analysis of Origanum onites and Ocimum gratissimum essential oils against Haemaphysalis doenitzi ticks.Parasites & vectors · 2025Article
- Article
- Over-expression and increased copy numbers of a cytochrome P450 and two UDP-glucuronosyltransferase genes in macrocyclic lactone resistant Psoroptes ovis of cattle.PLoS pathogens · 2025Article
- Whole Genome Sequencing Reveals Clade-Specific Genetic Variation in Blacklegged Ticks.Ecology and evolution · 2025Article
- A review of acaricides and their resistance mechanisms in hard ticks and control alternatives with synergistic agents.Acta tropica · 2025Review
- Ivermectin resistance mechanisms in ectoparasites: a scoping review.Parasitology research · 2024Article
- In Vivo Characterization of the Anti-Glutathione S-Transferase Antibody Using an In Vitro Mite Feeding Model.Vaccines · 2024Article
- Transcriptome Profiling ofBiomedicines · 2023Article
- Putative target sites in synganglion for novel ixodid tick control strategies.Ticks and tick-borne diseases · 2023Review
- Phenotypic and Target-Directed Screening Yields New Acaricidal Alternatives for the Control of Ticks.Molecules (Basel, Switzerland) · 2022Article
- Observing How Glutathione and S-Hexyl Glutathione Bind to Glutathione S-Transferase fromInternational journal of molecular sciences · 2022Article
- Molecular targets for the development of new acaricides againstParasitology · 2022Review
- Evaluation of acaricidal resistance status of Rhipicephalus microplus ticks from the hilly state (Uttarakhand) of India and evaluation of efficacy of a natural formulation for the management of resistant ticks.Experimental & applied acarology · 2021Article
- Effect of sublethal concentrations of the antiparasitic ivermectin on the polychaeta species Hediste diversicolor: biochemical and behavioral responses.Ecotoxicology (London, England) · 2021Article
- Comparative susceptibility of Rhipicephalus microplus collected from the northern state of India to coumaphos, malathion, deltamethrin, ivermectin, and fipronil.Tropical animal health and production · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The cattle tick Rhipicephalus microplus is one of the most important ectoparasites with great sanitary and economic impact for cattle rearing worldwide. Ivermectin is commonly used to control tick populations, but its use over the last 30 years has led to the development of resistant populations of R. microplus, and a concomitant loss of efficacy. In this context, we aimed to determine the metabolic mechanisms that contribute to ivermectin resistance in a resistant strain of this species. We performed lethal time bioassays with inhibitors of detoxifying enzymes and xenobiotic transporters (four detoxification pathways) using two strains of ticks: a susceptible strain, Mozo, and a resistant strain, Juarez. We used four inhibitors to test the involvement of different families of proteins responsible for detoxification of ivermectin, namely cytochrome P450, esterases, glutathione-S-transferase, and ATP Binding Cassette Transporters. We calculated the synergistic factor for each inhibitor and strain. To different degrees, all tested inhibitors altered the mortality rates in the strain Juarez, indicating that multiple mechanisms are responsible for the resistant phenotype. Detoxification mechanisms mediated by ABC transporters were observed to be the most important. Esterases, glutathione-S-transferases, and cytochrome-oxidases played less important roles in detoxification.
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