Evidence map›Paper›PMID 30120318›Full record

ArticleScientific reports2018

Phospholipidome of endothelial cells shows a different adaptation response upon oxidative, glycative and lipoxidative stress.

Simone Colombo, Tânia Melo, Marta Martínez-López, M Jesús Carrasco, M Rosário Domingues, Dolores Pérez-Sala, Pedro Domingues

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

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  15. Targeting Lipid Peroxidation for Cancer Treatment.Molecules (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Simone ColomboMass Spectrometry Centre, Department of Chemistry & QOPNA, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
Tânia MeloMass Spectrometry Centre, Department of Chemistry & QOPNA, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
Marta Martínez-LópezDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas, CSIC, Ramiro, de Maeztu, 9, 28040, Madrid, Spain.
M Jesús CarrascoDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas, CSIC, Ramiro, de Maeztu, 9, 28040, Madrid, Spain.
M Rosário DominguesMass Spectrometry Centre, Department of Chemistry & QOPNA, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal. mrd@ua.pt.
Dolores Pérez-SalaDepartment of Structural and Chemical Biology, Centro de Investigaciones Biológicas, CSIC, Ramiro, de Maeztu, 9, 28040, Madrid, Spain.ORCID 0000-0003-0600-665X
Pedro DominguesMass Spectrometry Centre, Department of Chemistry & QOPNA, University of Aveiro, Campus Universitário de Santiago, 3810-193, Aveiro, Portugal.
University of Aveiro · PTCentro de Investigaciones Biológicas Margarita Salas · ES

Funding

EC | Horizon 2020 (European Union Framework Programme for Research and Innovation) 675132
6 · The paper itself

Abstract

Endothelial dysfunction has been widely associated with oxidative stress, glucotoxicity and lipotoxicity and underlies the development of cardiovascular diseases (CVDs), atherosclerosis and diabetes. In such pathological conditions, lipids are emerging as mediators of signalling pathways evoking key cellular responses as expression of proinflammatory genes, proliferation and apoptosis. Hence, the assessment of lipid profiles in endothelial cells (EC) can provide valuable information on the molecular alterations underlying CVDs, atherosclerosis and diabetes. We performed a lipidomic approach based on hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) for the analysis of the phospholipidome of bovine aortic EC (BAEC) exposed to oxidative (H

Indexed as

AnimalsCardiovascular DiseasesCattleChromatography, LiquidEndothelial CellsHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxideHydrophobic and Hydrophilic InteractionsLipoproteins, LDLOxidative StressPhospholipidsSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryHydrogen PeroxideLipoproteins, LDLoxidized low density lipoproteinPhospholipids

Identifiers

PMID30120318
PMCPMC6097988
OpenAlexW2886824860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.