ArticleScientific reports2018
Including planocerid flatworms in the diet effectively toxifies the pufferfish, Takifugu niphobles.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Differential Accumulation and Excretion of Tetrodotoxin and 5,6,11-Trideoxytetrodotoxin in the Mussel Mytilus galloprovincialis Following Ingestion of Toxic Flatworm Larvae.Marine biotechnology (New York, N.Y.) · 2026Article
- Toxicity Assessment of 6-Deoxytetrodotoxin by Mouse Bioassay and Its Distribution in Pufferfish.Marine drugs · 2026Article
- Discovery and Functional Characterization of Kunitz-Type Toxins from the Tetrodotoxin-Bearing Flatworm Planocera Multitencaculata.Marine biotechnology (New York, N.Y.) · 2026Article
- Trophic Role of the Tetrodotoxin-Bearing Flatworm Plancera multitentaculata in the Marine Food Web.Marine biotechnology (New York, N.Y.) · 2026Article
- Animal medical systems from Apis to apes: history, recent advances and future perspectives.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Epidermal distribution of tetrodotoxin-rich cells in newly hatched larvae of Takifugu spp.Marine biotechnology (New York, N.Y.) · 2024Article
- Tetrodotoxin: The State-of-the-Art Progress in Characterization, Detection, Biosynthesis, and Transport Enrichment.Marine drugs · 2024Review
- Tissue Localization of Tetrodotoxin in the Flatworm Planocera multitentaculata (Platyhelminthes: Polycladida).Marine biotechnology (New York, N.Y.) · 2024Article
- Japanese Planocerid Flatworms: Difference in Composition of Tetrodotoxin and Its Analogs and the Effects of Ingestion by Toxin-Bearing Fishes in the Ryukyu Islands, Japan.Marine biotechnology (New York, N.Y.) · 2024Article
- The odor of a nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, is detected by specific olfactory sensory neurons of the green spotted puffers.Chemical senses · 2024Article
- Tetrodotoxin Detection in Japanese Bivalves: Toxification Status of Scallops.Marine biotechnology (New York, N.Y.) · 2023Article
- Assessing the Toxicity ofMarine drugs · 2023Article
- Article
- A Hotspot of TTX Contamination in the Adriatic Sea: Study on the Origin and Causative Factors.Marine drugs · 2022Article
- Changes in Tissue Distribution of Tetrodotoxin and Its Analogues in Association with Maturation in the Toxic Flatworm, Planocera multitentaculata.Marine biotechnology (New York, N.Y.) · 2022Article
- An almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an odorant for the grass puffer.Scientific reports · 2022Article
- Review
- A review of chemical defense in harlequin toads (Bufonidae:Toxicon: X · 2022Review
- Local Differences in the Toxin Amount and Composition of Tetrodotoxin and Related Compounds in Pufferfish (Toxins · 2022Article
- An Updated Review of Tetrodotoxin and Its Peculiarities.Marine drugs · 2022Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beginning with the larval stages, marine pufferfish such as Takifugu niphobles contain tetrodotoxin (TTX), an extremely potent neurotoxin. Although highly concentrated TTX has been detected in adults and juveniles of these fish, the source of the toxin has remained unclear. Here we show that TTX in the flatworm Planocera multitentaculata contributes to the toxification of the pufferfish throughout the life cycle of the flatworm. A species-specific PCR method was developed for the flatworm, and the specific DNA fragment was detected in the digesta of wild pufferfish adults. Predation experiments showed that flatworm larvae were eaten by the pufferfish juveniles, and that the two-day postprandial TTX content in these pufferfish was 20-50 μg/g. Predation experiments additionally showed flatworm adults were also eaten by pufferfish young, and after two days of feeding, TTX accumulated in the skin, liver and intestine of the pufferfish.
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