Evidence map›Paper›PMID 30120270›Full record

ArticleScientific reports2018

Membrane-Modulating Drugs can Affect the Size of Amyloid-β

Adree Khondker, Richard J Alsop, Sebastian Himbert, Jennifer Tang, An-Chang Shi, Adam P Hitchcock, Maikel C Rheinstädter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Adree KhondkerDepartment of Physics and Astronomy, McMaster University, Hamilton, Ontario, Canada.
Richard J AlsopDepartment of Physics and Astronomy, McMaster University, Hamilton, Ontario, Canada.
Sebastian HimbertDepartment of Physics and Astronomy, McMaster University, Hamilton, Ontario, Canada.
Jennifer TangDepartment of Physics and Astronomy, McMaster University, Hamilton, Ontario, Canada.
An-Chang ShiDepartment of Physics and Astronomy, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-1379-7162
Adam P HitchcockDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.
Maikel C RheinstädterDepartment of Physics and Astronomy, McMaster University, Hamilton, Ontario, Canada. rheinstadter@mcmaster.ca.ORCID 0000-0002-0558-7475
McMaster University · CA

Funding

CIHR
6 · The paper itself

Abstract

The formation of amyloid-β plaques is one of the hallmarks of Alzheimer's disease. The presence of an amphiphatic cell membrane can accelerate the formation of amyloid-β aggregates, making it a potential druggable target to delay the progression of Alzheimer's disease. We have prepared unsaturated anionic membranes made of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dimyristoyl-sn-glycero-3-phospho-L-serine (DMPS) and added the trans-membrane segment Aβ

Indexed as

Amyloid beta-PeptidesAnionsElectron Microscope TomographyLipid BilayersMembrane LipidsMicroscopy, Atomic ForceModels, TheoreticalMolecular Dynamics SimulationX-Ray DiffractionAmyloid beta-PeptidesAnionsLipid BilayersMembrane Lipids

Identifiers

PMID30120270
PMCPMC6098001
OpenAlexW2887989723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.