ArticleNature communications2018
Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed.
- Rare-Earth Nanomaterials for Advanced Theranostics of Atherosclerosis.Chemical & biomedical imaging · 2026Review
- Upconversion particle-based optical tweezers for sensing applications.Nature protocols · 2026Review
- Aminal-linked Covalent Organic Frameworks for Light Energy Upconversion.Angewandte Chemie (International ed. in English) · 2026Article
- Topology-driven energy transfer networks for upconversion stimulated emission depletion microscopy.Light, science & applications · 2025Article
- Harnessing Photo-Energy Conversion in Nanomaterials for Precision Theranostics.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Recent Trends in Upconversion Luminescent Inorganic Materials and Nanomaterials for Enhanced Photovoltaic Solar Cell and Biological Applications.Journal of fluorescence · 2025Review
- Chlorella-derived natural photosynthetic system for in situ energy metabolism enhancement in cardiomyocytes.Nature communications · 2025Article
- Instant noninvasive near-infrared deep brain stimulation using optoelectronic nanoparticles without genetic modification.Science advances · 2025Article
- Unlocking Multimodal Nonlinear Microscopy for Deep-Tissue Imaging under Continuous-Wave Excitation with Tunable Upconverting Nanoparticles.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Deep-Penetrating and High-Resolution Continuous-Wave Nonlinear Microscopy Based on Homologous Dual-Emission Upconversion Adaptive Optics.Nano letters · 2025Article
- Luminescent Lanthanides in Biorelated Applications: From Molecules to Nanoparticles and Diagnostic Probes to Therapeutics.Chemical reviews · 2025Review
- Multiplexed Shortwave Infrared Imaging Highlights Anatomical Structures in Mice.Angewandte Chemie (International ed. in English) · 2024Article
- Lanthanide ion-doped upconversion nanoparticles for low-energy super-resolution applications.Light, science & applications · 2024Review
- Article
- Recent Advances in Fluorescent Nanoparticles for Stimulated Emission Depletion Imaging.Biosensors · 2024Review
- High contrast breast cancer biomarker semi-quantification and immunohistochemistry imaging using upconverting nanoparticles.Biomedical optics express · 2024Article
- Multiplexed Short-wave Infrared Imaging Highlights Anatomical Structures in Mice.bioRxiv : the preprint server for biology · 2024Article
- Population Control of Upconversion Energy Transfer for Stimulation Emission Depletion Nanoscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- High-efficiency upconversion process in cobalt and neodymium doped graphene QDs for biomedical applications.Scientific reports · 2023Article
- Upconversion nanoscopy revealing surface heterogeneity of tumor-secreted extracellular vesicles.Light, science & applications · 2023Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Multiphoton fluorescence microscopy (MPM), using near infrared excitation light, provides increased penetration depth, decreased detection background, and reduced phototoxicity. Using stimulated emission depletion (STED) approach, MPM can bypass the diffraction limitation, but it requires both spatial alignment and temporal synchronization of high power (femtosecond) lasers, which is limited by the inefficiency of the probes. Here, we report that upconversion nanoparticles (UCNPs) can unlock a new mode of near-infrared emission saturation (NIRES) nanoscopy for deep tissue super-resolution imaging with excitation intensity several orders of magnitude lower than that required by conventional MPM dyes. Using a doughnut beam excitation from a 980 nm diode laser and detecting at 800 nm, we achieve a resolution of sub 50 nm, 1/20th of the excitation wavelength, in imaging of single UCNP through 93 μm thick liver tissue. This method offers a simple solution for deep tissue super resolution imaging and single molecule tracking.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.