Evidence map›Paper›PMID 30120153›Full record

ReviewThe Journal of biological chemistry2018

An elusive adenylate cyclase complicit in cholera is exposed.

Christoph O Randak

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Christoph O RandakStead Family Department of Pediatrics and the Lung Biology and Cystic Fibrosis Research Center of the Pappajohn Biomedical Institute, University of Iowa, Iowa City, Iowa 52242. Electronic address: christoph-randak@uiowa.edu.
University of Iowa · US

Funding

Probing adenylate kinase-dependent CFTR gating in vivo and as therapeutic targetR01DK107489 · NIDDK · UNIVERSITY OF IOWA · PI RANDAK, CHRISTOPH OSKAR · 2017 to 2020
$1.5M
NIDDK NIH HHS R01 DK107489
6 · The paper itself

Abstract

The intestinal consequences of cholera enterotoxin are caused by activation of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel through the actions of an as-yet-unknown adenylate cyclase. A new study hunts down this elusive enzyme, showing that mouse and human intestinal epithelium functionally and structurally pair adenylate cyclase isoform 6 (AC6) with CFTR. These findings provide important insights into the molecular mechanisms underlying the robust pathological activation of CFTR activity and promise new opportunities to treat cholera.

Indexed as

Adenylyl CyclasesAnimalsCholeraCystic Fibrosis Transmembrane Conductance RegulatorEnterotoxinsHumansIntestinal Mucosaadenylyl cyclase 6Adenylyl CyclasesCFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorEnterotoxins

Identifiers

PMID30120153
PMCPMC6102141
OpenAlexW2887785244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.