Evidence map›Paper›PMID 30120136›Full record

SynthesisNeurology2018

Work-relatedness of lumbosacral radiculopathy syndrome: Review and dose-response meta-analysis.

P Paul F M Kuijer, Jos H Verbeek, Andreas Seidler, Rolf Ellegast, Carel T J Hulshof, Monique H W Frings-Dresen, Henk F Van der Molen

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 13 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 13 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Association between night work and prostate cancer: a systematic review and meta-analysis.International archives of occupational and environmental health · 2024
    Pooled it
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  5. Guideline
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  9. Stigmatization from Work-Related COVID-19 Exposure: A Systematic Review with Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
  10. Pooled it
  11. Work-relatedness of inguinal hernia: a systematic review including meta-analysis and GRADE.Hernia : the journal of hernias and abdominal wall surgery · 2020
    Pooled it
  12. The risk of cytomegalovirus infection in daycare workers: a systematic review and meta-analysis.International archives of occupational and environmental health · 2020
    Pooled it
  13. Are Daycare Workers at a Higher Risk of Parvovirus B19 Infection? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2019
    Pooled it
  14. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

P Paul F M KuijerFrom the Academic Medical Center (P.P.F.M.K., C.T.J.H., M.H.W.F.-D., H.F.V.d.M.), Amsterdam, the Netherlands; Finnish Institute of Occupational Health (J.H.V.), Kuopio, Finland; Faculty of Medicine (A.S.), TU Dresden; and Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) (R.E.), Sankt Augustin, Germany. p.p.kuijer@amc.uva.nl.
Jos H VerbeekFrom the Academic Medical Center (P.P.F.M.K., C.T.J.H., M.H.W.F.-D., H.F.V.d.M.), Amsterdam, the Netherlands; Finnish Institute of Occupational Health (J.H.V.), Kuopio, Finland; Faculty of Medicine (A.S.), TU Dresden; and Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) (R.E.), Sankt Augustin, Germany.
Andreas SeidlerFrom the Academic Medical Center (P.P.F.M.K., C.T.J.H., M.H.W.F.-D., H.F.V.d.M.), Amsterdam, the Netherlands; Finnish Institute of Occupational Health (J.H.V.), Kuopio, Finland; Faculty of Medicine (A.S.), TU Dresden; and Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) (R.E.), Sankt Augustin, Germany.
Rolf EllegastFrom the Academic Medical Center (P.P.F.M.K., C.T.J.H., M.H.W.F.-D., H.F.V.d.M.), Amsterdam, the Netherlands; Finnish Institute of Occupational Health (J.H.V.), Kuopio, Finland; Faculty of Medicine (A.S.), TU Dresden; and Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) (R.E.), Sankt Augustin, Germany.
Carel T J HulshofFrom the Academic Medical Center (P.P.F.M.K., C.T.J.H., M.H.W.F.-D., H.F.V.d.M.), Amsterdam, the Netherlands; Finnish Institute of Occupational Health (J.H.V.), Kuopio, Finland; Faculty of Medicine (A.S.), TU Dresden; and Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) (R.E.), Sankt Augustin, Germany.
Monique H W Frings-DresenFrom the Academic Medical Center (P.P.F.M.K., C.T.J.H., M.H.W.F.-D., H.F.V.d.M.), Amsterdam, the Netherlands; Finnish Institute of Occupational Health (J.H.V.), Kuopio, Finland; Faculty of Medicine (A.S.), TU Dresden; and Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) (R.E.), Sankt Augustin, Germany.
Henk F Van der MolenFrom the Academic Medical Center (P.P.F.M.K., C.T.J.H., M.H.W.F.-D., H.F.V.d.M.), Amsterdam, the Netherlands; Finnish Institute of Occupational Health (J.H.V.), Kuopio, Finland; Faculty of Medicine (A.S.), TU Dresden; and Institute for Occupational Safety and Health of the German Social Accident Insurance (IFA) (R.E.), Sankt Augustin, Germany.
TU Dresden · DEFinnish Institute of Occupational Health · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveClinicians need to know whether lumbosacral radiculopathy syndrome (LRS) can be attributed to work. This review describes what work-related risk factors are associated with LRS.

methodsA systematic review was performed in PubMed and Embase. Inclusion criteria were that LRS was diagnosed by a clinician and workers exposed to work-related risk factors were compared to workers less or not exposed. A quality assessment and a meta-analysis were performed, including a dose-response analysis.

resultsThe search resulted in 7,350 references and 24 studies that fulfilled the inclusion criteria: 19 studies were rated as having a high risk of bias and 5 as having a low risk of bias. The median number of LRS patients per study were 209 (interquartile range 124-504) and the total number of participants was 10,142. The meta-analysis revealed significant associations with heavy physically demanding work (odds ratio [OR] 2.03, 95% confidence interval [CI] 1.48-2.79), bending or twisting of the trunk (OR 2.43, 95% CI 1.67-3.55), and lifting and carrying in combination with bending or twisting of the trunk (OR 2.84, 95% CI 2.18-3.69). No significant associations were found for professional driving (OR 1.46, 95% CI 0.90-2.35) or sitting (OR 1.08, 95% CI 0.49-2.38). A dose-response relation was present per 5 years of exposure for bending (OR 1.12, 95% CI 1.04-1.20), lifting (OR 1.08, 95% CI 1.02-1.14) and the combination of bending and lifting (OR 1.14, 95% CI 1.01-1.29).

conclusionsModerate to high-quality evidence is available that LRS can be classified as a work-related disease depending on the level of exposure to bending of the trunk or lifting and carrying. Professional driving and sitting were not significantly associated with LRS.

Indexed as

Cauda Equina SyndromeHumansOccupational Diseases

Identifiers

PMID30120136
PMCPMC6161552
OpenAlexW2886962121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.