Evidence map›Paper›PMID 30120133›Full record

Trial reportNeurology2018

Removing high-frequency oscillations: A prospective multicenter study on seizure outcome.

Julia Jacobs, Joyce Y Wu, Piero Perucca, Rina Zelmann, Malenka Mader, Francois Dubeau, Gary W Mathern, Andreas Schulze-Bonhage, Jean Gotman

Abstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Association between Removal of High-Frequency Oscillations and the Effect of Epilepsy Surgery: A Meta-Analysis.Journal of neurological surgery. Part A, Central European neurosurgery · 2024
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  18. Fast ripple band high-frequency activity associated with thalamic sleep spindles in pediatric epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
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51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Julia JacobsFrom the Department of Neuropediatrics and Muscular Diseases (J.J., M.M.) and Epilepsy Center (J.J., A.S.-B.), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Division of Pediatric Neurology (J.Y.W., G.W.M.), David Geffen School of Medicine and Mattel Children's Hospital UCLA, Los Angeles, CA; and Montreal Neurological Institute (P.P., R.Z., F.D., J.G.), McGill University, Quebec, Canada. julia.jacobs@gmx.de.
Joyce Y WuFrom the Department of Neuropediatrics and Muscular Diseases (J.J., M.M.) and Epilepsy Center (J.J., A.S.-B.), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Division of Pediatric Neurology (J.Y.W., G.W.M.), David Geffen School of Medicine and Mattel Children's Hospital UCLA, Los Angeles, CA; and Montreal Neurological Institute (P.P., R.Z., F.D., J.G.), McGill University, Quebec, Canada.
Piero PeruccaFrom the Department of Neuropediatrics and Muscular Diseases (J.J., M.M.) and Epilepsy Center (J.J., A.S.-B.), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Division of Pediatric Neurology (J.Y.W., G.W.M.), David Geffen School of Medicine and Mattel Children's Hospital UCLA, Los Angeles, CA; and Montreal Neurological Institute (P.P., R.Z., F.D., J.G.), McGill University, Quebec, Canada.
Rina ZelmannFrom the Department of Neuropediatrics and Muscular Diseases (J.J., M.M.) and Epilepsy Center (J.J., A.S.-B.), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Division of Pediatric Neurology (J.Y.W., G.W.M.), David Geffen School of Medicine and Mattel Children's Hospital UCLA, Los Angeles, CA; and Montreal Neurological Institute (P.P., R.Z., F.D., J.G.), McGill University, Quebec, Canada.
Malenka MaderFrom the Department of Neuropediatrics and Muscular Diseases (J.J., M.M.) and Epilepsy Center (J.J., A.S.-B.), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Division of Pediatric Neurology (J.Y.W., G.W.M.), David Geffen School of Medicine and Mattel Children's Hospital UCLA, Los Angeles, CA; and Montreal Neurological Institute (P.P., R.Z., F.D., J.G.), McGill University, Quebec, Canada.
Francois DubeauFrom the Department of Neuropediatrics and Muscular Diseases (J.J., M.M.) and Epilepsy Center (J.J., A.S.-B.), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Division of Pediatric Neurology (J.Y.W., G.W.M.), David Geffen School of Medicine and Mattel Children's Hospital UCLA, Los Angeles, CA; and Montreal Neurological Institute (P.P., R.Z., F.D., J.G.), McGill University, Quebec, Canada.
Gary W MathernFrom the Department of Neuropediatrics and Muscular Diseases (J.J., M.M.) and Epilepsy Center (J.J., A.S.-B.), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Division of Pediatric Neurology (J.Y.W., G.W.M.), David Geffen School of Medicine and Mattel Children's Hospital UCLA, Los Angeles, CA; and Montreal Neurological Institute (P.P., R.Z., F.D., J.G.), McGill University, Quebec, Canada.
Andreas Schulze-BonhageFrom the Department of Neuropediatrics and Muscular Diseases (J.J., M.M.) and Epilepsy Center (J.J., A.S.-B.), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Division of Pediatric Neurology (J.Y.W., G.W.M.), David Geffen School of Medicine and Mattel Children's Hospital UCLA, Los Angeles, CA; and Montreal Neurological Institute (P.P., R.Z., F.D., J.G.), McGill University, Quebec, Canada.
Jean GotmanFrom the Department of Neuropediatrics and Muscular Diseases (J.J., M.M.) and Epilepsy Center (J.J., A.S.-B.), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Division of Pediatric Neurology (J.Y.W., G.W.M.), David Geffen School of Medicine and Mattel Children's Hospital UCLA, Los Angeles, CA; and Montreal Neurological Institute (P.P., R.Z., F.D., J.G.), McGill University, Quebec, Canada.

Funding

Toward better characterization and clinical trial readiness for targeting neuropsychiatric manifestations in PTEN pathogenic variantsU54NS092090 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI MUSTAFA SAHIN · 2014 to 2026
$20.1M
Early Biomarkers of Autism Spectrum Disorders in infants with Tuberous SclerosisU01NS082320 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI KRUEGER, DARCY, SAHIN, MUSTAFA · 2012 to 2018
$13.3M
Preventing Epilepsy using Vigabatrin in Infants with Tuberous Sclerosis ComplexU01NS092595 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BEBIN, MARTINA · 2016 to 2020
$7.1M
High Frequency Oscillation as a Biomarker in Childhood EpilepsyR01NS082649 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WU, JOYCE Y · 2013 to 2017
$1.7M
Potential EEG biomarkers and antiepileptogenic strategies for epilepy in TSCP20NS080199 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BEBIN, MARTINA · 2012 to 2014
$966k
NINDS NIH HHS P20 NS080199NINDS NIH HHS R01 NS082649NINDS NIH HHS U01 NS082320NINDS NIH HHS U01 NS092595NINDS NIH HHS U54 NS092090
6 · The paper itself

Abstract

objectiveTo evaluate the use of interictal high-frequency oscillations (HFOs) in epilepsy surgery for prediction of postsurgical seizure outcome in a prospective multicenter trial.

methodsWe hypothesized that a seizure-free outcome could be expected in patients in whom the surgical planning included the majority of HFO-generating brain tissue while a poor seizure outcome could be expected in patients in whom only a few such areas were planned to be resected. Fifty-two patients were included from 3 tertiary epilepsy centers during a 1-year period. Ripples (80-250 Hz) and fast ripples (250-500 Hz) were automatically detected during slow-wave sleep with chronic intracranial EEG in 2 centers and acute intraoperative electrocorticography in 1 patient.

resultsThere was a correlation between the removal of HFO-generating regions and seizure-free outcome at the group level for all patients. No correlation was found, however, for the center-specific analysis, and an individual prognostication of seizure outcome was true in only 36 patients (67%). Moreover, some patients became seizure-free without removal of the majority of HFO-generating tissue. The investigation of influencing factors, including comparisons of visual and automatic analysis, using a threshold analysis for areas with high HFO activity, and excluding contacts bordering the resection, did not result in improved prognostication.

conclusionsOn an individual patient level, a prediction of outcome was not possible in all patients. This may be due to the analysis techniques used. Alternatively, HFOs may be less specific for epileptic tissue than earlier studies have indicated.

Indexed as

AdolescentAdultBrain WavesChildChild, PreschoolElectrocorticographyElectroencephalographyFemaleHumansInfantMaleMiddle AgedNeurosurgical ProceduresProspective StudiesSeizuresTreatment Outcome

Identifiers

PMID30120133
PMCPMC6140372

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.