Evidence map›Paper›PMID 30120122›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1.

Katherine Walwyn-Brown, Karolin Guldevall, Mezida Saeed, Daniela Pende, Björn Önfelt, Andrew S MacDonald, Daniel M Davis

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Unconventional functions of natural killer cells in homeostasis and disease.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Natural killer cells in the lung: potential role in asthma and virus-induced exacerbation?European respiratory review : an official journal of the European Respiratory Society · 2023
    Review
  8. Circulating CXCR5Clinical & translational immunology · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Impact of Polyvalent Mechanical Bacterial Lysate on lymphocyte number and activity in asthmatic children: a randomized controlled trial.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Katherine Walwyn-BrownManchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.ORCID 0000-0003-2325-5180
Karolin GuldevallDepartment of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, SE-106 91 Stockholm, Sweden.ORCID 0000-0003-1016-2460
Mezida SaeedManchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.
Daniela PendeLaboratorio Immunologia, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Policlinico San Martino, 16132 Genova, Italy; and.ORCID 0000-0003-1565-451X
Björn ÖnfeltDepartment of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Solna, SE-106 91 Stockholm, Sweden.
Andrew S MacDonaldManchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom.ORCID 0000-0002-5356-1149
Daniel M DavisManchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom; daniel.davis@manchester.ac.uk.ORCID 0000-0002-9182-291X
University of Manchester · GBScience for Life Laboratory · SEOspedale Policlinico San Martino · IT

Funding

Medical Research Council G1001044Medical Research Council MR/K501311/1Wellcome Trust 110091
6 · The paper itself

Abstract

Cross-talk between NK cells and dendritic cells (DCs) is important in Th1 immune responses, including antitumor immunity and responses to infections. DCs also play a crucial role in polarizing Th2 immunity, but the impact of NK cell-DC interactions in this context remains unknown. In this study, we stimulated human monocyte-derived DCs in vitro with different pathogen-associated molecules: LPS or polyinosinic-polycytidylic acid, which polarize a Th1 response, or soluble egg Ag from the helminth worm

Indexed as

AnimalsAntigens, Differentiation, T-LymphocyteAntigens, HelminthCell DifferentiationCells, CulturedCytotoxicity, ImmunologicDendritic CellsHumansKiller Cells, NaturalLipopolysaccharidesNatural Cytotoxicity Triggering Receptor 3Pathogen-Associated Molecular Pattern MoleculesPoly I-CSchistosoma mansoniTh1 CellsTh2 CellsAntigens, Differentiation, T-LymphocyteAntigens, HelminthLipopolysaccharidesNatural Cytotoxicity Triggering Receptor 3NCR3 protein, humanPathogen-Associated Molecular Pattern MoleculesPoly I-CT Lineage-Specific Activation Antigen 1

Identifiers

PMID30120122
PMCPMC6139540
OpenAlexW2886813640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.