ReviewCurrent opinion in neurobiology2019
Regulation of synaptic plasticity in hippocampal area CA2.
Review in Current opinion in neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 58 citations in OpenAlex.
- Hippocampal CA1 and CA2 dendritic compartment-specific differences in mitochondrial form and function.Progress in neurobiology · 2026Article
- Flexible and scalable inference of spatially varying correlation in spatial transcriptomics with spCorr.Genome research · 2026Article
- Functional transition of CA2 pyramidal neurons along the proximodistal axis determines resonance frequency preference.Scientific reports · 2026Article
- D1/D5 receptor activation promotes long-term potentiation and synaptic tagging/capture in hippocampal area CA2.The FEBS journal · 2026Article
- A dendrite-resolved,bioRxiv : the preprint server for biology · 2026Article
- The how and why for multiple forms of hippocampal LTP.Frontiers in synaptic neuroscience · 2026Review
- From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2.Hippocampus · 2026Review
- Hippocampal cell- and circuit-specific differences in mitochondrial form and function.bioRxiv : the preprint server for biology · 2025Article
- Thrombospondin-1 regulates synaptic transmission in hippocampal field CA2 and social behavior in mice.Neurobiology of disease · 2025Article
- Noncanonical circuits, states, and computations of the hippocampus.Science (New York, N.Y.) · 2025Review
- Differential expression of long-term depression, and synaptic tagging and capture in mouse hippocampal area CA2 synapses.PNAS nexus · 2025Article
- MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity.Scientific reports · 2025Article
- Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Identification of hippocampal area CA2 in hamster and vole brain.The Journal of comparative neurology · 2024Article
- Identification of hippocampal area CA2 in hamster and vole brain.bioRxiv : the preprint server for biology · 2024Article
- Article
- Alteration of hippocampal CA2 plasticity and social memory in adult rats impacted by juvenile stress.Hippocampus · 2023Article
- Estimation of cAMP binding in hippocampus CA1 field by a fluorescent probe.Frontiers in cell and developmental biology · 2023Article
- Neuropeptides and small-molecule amine transmitters: cooperative signaling in the nervous system.Cellular and molecular life sciences : CMLS · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Synaptic plasticity in the hippocampus is thought to play a vital role in both the refinement of neuronal circuits during development and in learning in the mature brain. Synapses in hippocampal area CA1 are known for a robust capacity for long-term potentiation (LTP), whereas synapses in the stratum radiatum of hippocampal area CA2 are particularly resistant to such changes. Although we have yet to fully understand the mechanisms behind this resistance to plasticity, a number of genes and extracellular matrix components highly expressed in CA2 appear to function as molecular brakes on plasticity and develop postnatally in the rodent brain. Curiously, the developmental profile of several CA2-enriched molecules is suggestive of a still undefined critical window of plasticity in the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.