ArticleCanadian journal of ophthalmology. Journal canadien d'ophtalmologie2018
Retinal thickness measurements in sickle cell patients with HbSS and HbSC genotype.
Article in Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Retinal microvascular alterations in sickle cell disease: a systematic review and meta-analysis of OCTA findings based on genotype and stages of retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Pooled it
- Genetic, clinical, and biological risk factors associated with optic nerve thinning in sickle cell disease.Eye (London, England) · 2026Article
- Correlations Between Visual Field Defects and Macular Thinning in Sickle Cell Disease.Investigative ophthalmology & visual science · 2025Article
- Salmon patch maculopathy: An amblyogenic complication of pediatric sickle cell retinopathy.American journal of ophthalmology case reports · 2024Article
- Artificial intelligence for improving sickle cell retinopathy diagnosis and management.Eye (London, England) · 2021Review
- Central macular thickness in patients with sickle cell disease and no signs of retinopathy: a cross-sectional study of Jordanian patients.The Journal of international medical research · 2021Article
- Chronic Effects of e-Cigarette Aerosol Inhalation on Macular Perfusion Assessed Using OCT Angiography.Journal of vitreoretinal diseasesArticle
- Automated Quantitative Assessment of Retinal Vascular Tortuosity in Patients with Sickle Cell Disease.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTemporal macula thinning has been reported in sickle cell patients, but it remains unclear if there is a difference between HbSS and HbSC genotypes. We aimed to quantitatively compare macular thickness between eyes with HbSS and HbSC genotype.
designRetrospective descriptive study.
methodsConsecutive patients seen over a 5.5-year period in the Ophthalmology Department at St Thomas' Hospital, London, were identified. Macular optical coherence tomography images were retrospectively analyzed. The retinal thickness in all 9 subfields of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid was compared between HbSS and HbSC eyes. Right eyes and left eyes were analyzed independently, as well as averaged measurements from both eyes. Comparison was made between the 2 genotypes, adjusting for age and sex, and for multiple testing. Scans were excluded in cases of poor fixation or ocular comorbidity affecting retinal thickness.
results132 HbSC and 120 HbSS patients were identified. Scans from 166 right and 153 left eyes were included (with approximately equal numbers of HbSS and HbSC genotypes). Mean retinal thickness was lower in HbSS eyes compared with HbSC eyes in all subfields of the ETDRS grid, but in most subfields the difference was <10 microns. Differences reached statistical significance for outer superior, inferior, and temporal subfields and the inner temporal subfield (p < 0.05).
conclusionAlthough the HbSC genotype is more strongly associated with proliferative retinopathy, HbSS patients had on average more macular thinning.
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