ArticleLipids in health and disease2018
Vitamin D receptor polymorphism rs2228570 is significantly associated with risk of dyslipidemia and serum LDL levels in Chinese Han population.
Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Vitamin D receptor gene variations and their association with cardiometabolic risk and microvascular complications in metabolic dysfunction-associated steatotic liver disease: evidence from a Turkish cohort.Laboratory medicine · 2026Article
- Association between dyslipidemia and vitamin D deficiency: a cross-sectional study in Chinese healthy population.Frontiers in endocrinology · 2025Article
- A review of vitamin D deficiency and vitamin D receptor polymorphisms in endocrine-related disorders.Clinical and experimental pediatrics · 2025Article
- Review
- The vitamin D receptor TaqI TT genotype is associated with type 1 diabetes in the Black South African population.Journal of nutritional science · 2024Observational
- Vitamin D level regulates serum lipids discrepantly in adults with and without dyslipidemia.Endocrine connections · 2023Article
- Association of vitamin D and polymorphisms of its receptor with antiviral therapy in pregnant women with hepatitis B.World journal of gastroenterology · 2023Article
- Effects of Vitamin D Receptor Genotype on Lipid Profiles and Retinopathy Risk in Type 2 Diabetes Patients: A Pilot Study.Journal of personalized medicine · 2022Article
- Vitamin D receptor gene polymorphisms in atopy.Immunity, inflammation and disease · 2021Review
- The association between vitamin D receptor polymorphisms and tissue-specific insulin resistance in human obesity.International journal of obesity (2005) · 2021Article
- Vitamin D receptor geneTranslational pediatrics · 2021Article
- Association of Vitamin D Receptor Gene Polymorphisms with Metabolic Syndrome in Chinese Children.International journal of general medicine · 2021Article
- Association Between Single Nucleotide Polymorphisms in the Vitamin D Receptor and Incidence of Dry Eye Disease in Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Strong association between VDR FokI (rs2228570) gene variant and serum vitamin D levels in Turkish Cypriots.Molecular biology reports · 2019Article
- Vitamin D receptor gene polymorphisms are associated with triceps skin fold thickness and body fat percentage but not with body mass index or waist circumference in Han Chinese.Lipids in health and disease · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
backgroundThe goal of this study was to determine if vitamin D receptor (VDR) gene polymorphisms underlie susceptibility to dyslipidemia in a Chinese Han population.
methodsThree tag single nucleotide polymorphisms (SNPs) (rs11574129, rs2228570, and rs739837) were genotyped using TaqMan assays to determine VDR SNP associations with dyslipidemia. We genotyped 877 cases of dyslipidemia from a normotensive, non-diabetes mellitus population and 1822 non-dyslipidemia subjects in a stage I study. In a follow-up stage II study, we included a larger sample of 3124 controls and 1679 cases with dyslipidemia. Finally, we explored the potential molecular mechanism for the SNP associations using molecular modeling analysis.
resultsWe found a significant association between SNP rs2228570 and dyslipidemia in the additive (adjusted odds ratio (OR) = 1.255, 95% Confidence Interval (CI) = (1.118-1.409), P < 0.001), dominant (OR = 1.384, 95% CI = 1.384 (1.136-1.6), P = 0.001) and recessive models (OR = 1.356, 95%CI = 1.1-1.671, P = 0.004) in stage I. We further established that the rs2228570 variant was significantly associated with dyslipidemia in the additive (adjusted OR = 1.146, 95% CI = 1.053-1247, P = 0.002), dominant (OR = 1.184, 95%CI =1.018-1.376, P = 0.028) and recessive models (OR = 1.209, 95%CI = 1.064-1.374, P = 0.004) in stage II. The TT genotype was significantly higher (4.93 ± 0.75 mmol/L) compared to the TC (4.67 ± 0.47 mmol/L) or CC (4.66 ± 0.44 mmol/L) genotype (P = 0.01) in cases with elevated low-density lipoprotein cholesterol (LDL-C) levels. In contrast, the cases with the TT genotype had significantly lower serum 25(OH)D levels (18.43 ± 5.04 ng/ mL) compared to the TC (26.24 ± 4.16 ng/mL) and CC (36.76 ± 8.10 ng/ mL) genotypes (P < 0.001). Multivariable linear regression analysis indicated that the rs2228750 genotype significantly correlated with serum low-density lipoprotein-C (LDL-C) levels in cases with dyslipidemia. Using molecular modeling analysis, we further found that the rs2228570 variant changed the structure and the stability of VDR and altered the binding energy of its ligand.
conclusionsThe VDR rs2228570 variant may increase susceptibility to dyslipidemia in the Chinese Han population.
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