Evidence map›Paper›PMID 30118815›Full record

ArticleThe Journal of steroid biochemistry and molecular biology2019

Identification of zebrafish steroid sulfatase and comparative analysis of the enzymatic properties with human steroid sulfatase.

Katsuhisa Kurogi, Maki Yoshihama, Frederick E Williams, Naoya Kenmochi, Yoichi Sakakibara, Masahito Suiko, Ming-Cheh Liu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of steroid biochemistry and molecular biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Dehydroepiandrosterone (DHEA) as a tool for conservation.Environmental monitoring and assessment · 2026
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Katsuhisa KurogiDepartment of Pharmacology, College of Pharmacy, University of Toledo Health Science Campus, Toledo, OH 43614, USA; Biochemistry and Applied Biosciences, University of Miyazaki, Miyazaki 889-2192, Japan.
Maki YoshihamaDepartment of Pharmacology, College of Pharmacy, University of Toledo Health Science Campus, Toledo, OH 43614, USA; Frontier Research Center, University of Miyazaki, Miyazaki 889-2192, Japan.
Frederick E WilliamsDepartment of Pharmacology, College of Pharmacy, University of Toledo Health Science Campus, Toledo, OH 43614, USA.
Naoya KenmochiFrontier Research Center, University of Miyazaki, Miyazaki 889-2192, Japan.
Yoichi SakakibaraBiochemistry and Applied Biosciences, University of Miyazaki, Miyazaki 889-2192, Japan.
Masahito SuikoBiochemistry and Applied Biosciences, University of Miyazaki, Miyazaki 889-2192, Japan.
Ming-Cheh LiuDepartment of Pharmacology, College of Pharmacy, University of Toledo Health Science Campus, Toledo, OH 43614, USA. Electronic address: ming.liu@utoledo.edu.
University of Miyazaki · JPUniversity of Toledo · US

Funding

Ontogeny of the Phase II cytosolic sulfotransferases and adverse drug reactionsR03HD071146 · NICHD · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI LIU, MING-CHEH · 2012 to 2013
$146k
NICHD NIH HHS R03 HD071146
6 · The paper itself

Abstract

Steroid sulfatase (STS) plays an important role in the regulation of steroid hormones. Metabolism of steroid hormones in zebrafish has been investigated, but the action of steroid sulfatase remains unknown. In this study, a zebrafish sts was cloned, expressed, purified, and characterized in comparison with the orthologous human enzyme. Enzymatic assays demonstrated that similar to human STS, zebrafish Sts was most active in catalyzing the hydrolysis of estrone-sulfate and estradiol-sulfate, among five steroid sulfates tested as substrates. Kinetic analyses revealed that the K

Indexed as

Amino Acid SequenceAnimalsCatalysisCationsCloning, MolecularDehydroepiandrosterone SulfateEnzyme InhibitorsEstradiolEstroneHumansSteryl-SulfataseZebrafishCationsDehydroepiandrosterone SulfateEnzyme InhibitorsEstradiolestradiol sulfateEstroneestrone sulfateSteryl-SulfataseSteroid sulfataseSteroid sulfatesZebrafish

Identifiers

PMID30118815
PMCPMC6289849
OpenAlexW2886085846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.