Observational studyResuscitation2018
End-tidal carbon dioxide during pediatric in-hospital cardiopulmonary resuscitation.
Observational study in Resuscitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 8. Pediatric advanced life support.Clinical and experimental emergency medicine · 2026Guideline
- 2020 Korean Guidelines for Cardiopulmonary Resuscitation. Part 7. Pediatric advanced life support.Clinical and experimental emergency medicine · 2021Guideline
- Chest compressions superimposed with sustained inflations during cardiopulmonary resuscitation in asphyxiated pediatric piglets.Pediatric research · 2024Trial
- Trial
- Chest compression synchronized ventilation versus chest compression asynchronized ventilation in asphyxiated pediatric piglets-a randomized animal trial.Pediatric research · 2026Article
- Is End-Tidal Carbon Dioxide Indicative of Chest Compression Quality in Pediatric Out-of-Hospital Cardiac Arrest? A Video Review Study.Journal of the American College of Emergency Physicians open · 2026Article
- Seeing beyond the numbers: capnography as a vital tool in pediatric emergency care.International journal of emergency medicine · 2026Review
- Pulse check accuracy in pediatrics during resuscitation: a systematic review.Resuscitation plus · 2025Review
- Resuscitation arterial waveform quantification and outcomes in pediatric bidirectional Glenn and Fontan patients.Pediatric research · 2025Article
- Cardiopulmonary resuscitation employing only abdominal compressions in infants after cardiac surgery: A secondary sub-analysis of the ICU-RESUS study.Resuscitation plus · 2024Article
- Associations Between End-Tidal Carbon Dioxide During Pediatric Cardiopulmonary Resuscitation, Cardiopulmonary Resuscitation Quality, and Survival.Circulation · 2024Observational
- Review
- Prediction of Return of Spontaneous Circulation in a Pediatric Swine Model of Cardiac Arrest Using Low-Resolution Multimodal Physiological Waveforms.IEEE journal of biomedical and health informatics · 2023Article
- Clinician-reported physiologic monitoring of cardiopulmonary resuscitation quality during pediatric in-hospital cardiac arrest: A propensity-weighted cohort study.Resuscitation · 2023Article
- Novel approaches to capturing and using continuous cardiorespiratory physiological data in hospitalized children.Pediatric research · 2023Review
- Resuscitation practices in hospitals caring for children: Insights from get with the guidelines-resuscitation.Resuscitation plus · 2022Article
- Use of an end-tidal carbon dioxide-guided algorithm during cardiopulmonary resuscitation improves short-term survival in paediatric swine.Resuscitation plus · 2021Article
- Focused echocardiography, end-tidal carbon dioxide, arterial blood pressure or near-infrared spectroscopy monitoring during paediatric cardiopulmonary resuscitation: A scoping review.Resuscitation plus · 2021Article
- Pediatric In-Hospital Cardiac Arrest and Cardiopulmonary Resuscitation in the United States: A Review.JAMA pediatrics · 2021Review
- [Paediatric Life Support].Notfall & rettungsmedizin · 2021Review
Corrections and comments
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Authors and funding
18 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundBased on laboratory cardiopulmonary resuscitation (CPR) investigations and limited adult data, the American Heart Association Consensus Statement on CPR Quality recommends titrating CPR performance to achieve end-tidal carbon dioxide (ETCO2) >20 mmHg.
aimsWe prospectively evaluated whether ETCO2 > 20 mmHg during CPR was associated with survival to hospital discharge.
methodsChildren ≥37 weeks gestation in Collaborative Pediatric Critical Care Research Network intensive care units with chest compressions for ≥1 min and ETCO2 monitoring prior to and during CPR between July 1, 2013 and June 31, 2016 were included. ETCO2 and Utstein-style cardiac arrest data were collected. Multivariable Poisson regression models with robust error estimates were used to estimate relative risk of outcomes.
resultsBlinded investigators analyzed ETCO2 waveforms from 43 children. During CPR, the median ETCO2 was 23 mmHg [quartiles, 16 and 28 mmHg], median ventilation rate was 29 breaths/min [quartiles, 24 and 35 breaths/min], and median duration of CPR was 5 min [quartiles, 2 and 16 min]. Return of spontaneous circulation occurred after 71% of CPR events and 37% of patients survived to hospital discharge. For children with mean ETCO2 during CPR > 20 mmHg, the adjusted relative risk for survival was 0.92 (0.41, 2.08), p = 0.84. The median mean ETCO2 among children who survived to hospital discharge was 20 mmHg [quartiles; 15, 28 mmHg] versus 23 mmHg [16, 28 mmHg] among non-survivors.
conclusionMean ETCO2 > 20 mmHg during pediatric in-hospital CPR was not associated with survival to hospital discharge, and ETCO2 was not different in survivors versus non-survivors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.