ReviewNeuroscience research2019
Circuit mechanisms and computational models of REM sleep.
Review in Neuroscience research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Low-dimensional population dynamics in the brainstem gate REM sleep.Nature neuroscience · 2026Article
- Sleep and circadian rhythm disruptions in animal models of temporal lobe epilepsy.Frontiers in neuroscience · 2026Review
- Dream and its interpretation: scientific perspective.Internal and emergency medicine · 2025Review
- Sleep, Glial Function, and the Endocannabinoid System: Implications for Neuroinflammation and Sleep Disorders.International journal of molecular sciences · 2024Review
- Morphological characteristics of cerebellum, pons and thalamus in Reccurent isolated sleep paralysis - A pilot study.Frontiers in neuroanatomy · 2024Article
- The Ponto-Geniculo-Occipital (PGO) Waves in Dreaming: An Overview.Brain sciences · 2023Review
- Pontine Waves Accompanied by Short Hippocampal Sharp Wave-Ripples During Non-rapid Eye Movement Sleep.Sleep · 2023Article
- Understanding Sleep Regulation in Normal and Pathological Conditions, and Why It Matters.Journal of Huntington's disease · 2023Review
- Sleep, Narcolepsy, and Sodium Oxybate.Current neuropharmacology · 2022Article
- Review
- Mutual Interactions between Brain States and Alzheimer's Disease Pathology: A Focus on Gamma and Slow Oscillations.Biology · 2021Review
- Regulation of microRNA Expression in Sleep Disorders in Patients with Epilepsy.International journal of molecular sciences · 2021Review
- Aspects of tree shrew consolidated sleep structure resemble human sleep.Communications biology · 2021Article
- Melanins as Sustainable Resources for Advanced Biotechnological Applications.Global challenges (Hoboken, NJ) · 2021Review
- Alterations of neural network organization during REM sleep in women: implication for sex differences in vulnerability to mood disorders.Biology of sex differences · 2020Article
- State-dependent brainstem ensemble dynamics and their interactions with hippocampus across sleep states.eLife · 2020Article
- Neural and Homeostatic Regulation of REM Sleep.Frontiers in psychology · 2020Review
- Pathway-Dependent Regulation of Sleep Dynamics in a Network Model of the Sleep-Wake Cycle.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rapid eye movement (REM) sleep or paradoxical sleep is an elusive behavioral state. Since its discovery in the 1950s, our knowledge of the neuroanatomy, neurotransmitters and neuropeptides underlying REM sleep regulation has continually evolved in parallel with the development of novel technologies. Although the pons was initially discovered to be responsible for REM sleep, it has since been revealed that many components in the hypothalamus, midbrain, pons, and medulla also contribute to REM sleep. In this review, we first provide an up-to-date overview of REM sleep-regulating circuits in the brainstem and hypothalamus by summarizing experimental evidence from neuroanatomical, neurophysiological and gain- and loss-of-function studies. Second, because quantitative approaches are essential for understanding the complexity of REM sleep-regulating circuits and because mathematical models have provided valuable insights into the dynamics underlying REM sleep genesis and maintenance, we summarize computational studies of the sleep-wake cycle, with an emphasis on REM sleep regulation. Finally, we discuss outstanding issues for future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.