ArticleMolecular cell2018
Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program.
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Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Histone lysine demethylases in breast cancer: molecular mechanisms, biological functions, and therapeutic intervention.Molecular cancer · 2025Review
- Proteasome Inhibition Reprograms Chromatin Landscape in Breast Cancer.Cancer research communications · 2024Article
- BAP18 facilitates CTCF-mediated chromatin accessible to regulate enhancer activity in breast cancer.Cell death and differentiation · 2023Article
- Transcriptional enhancers at 40: evolution of a viral DNA element to nuclear architectural structures.Trends in genetics : TIG · 2022Review
- Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ERNature communications · 2022Article
- The landscape of promoter-centred RNA-DNA interactions in rice.Nature plants · 2022Article
- NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.RNA biology · 2021Article
- Signalosome-Regulated Serum Response Factor Phosphorylation Determining Myocyte Growth in Width Versus Length as a Therapeutic Target for Heart Failure.Circulation · 2020Article
- Epigenomics-based identification of oestrogen-regulated long noncoding RNAs in ER+ breast cancer.RNA biology · 2020Article
- Enhancer RNAs Mediate Estrogen-Induced Decommissioning of Selective Enhancers by Recruiting ERα and Its Cofactor.Cell reports · 2020Article
- Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity.The Journal of biological chemistry · 2020Article
- Chromatin-associated RNAs as facilitators of functional genomic interactions.Nature reviews. Genetics · 2019Review
- Analysis of RNA polymerase II ubiquitylation and proteasomal degradation.Methods (San Diego, Calif.) · 2019Article
- Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate.Frontiers in cell and developmental biology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Yuliang TanHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Chunyu JinHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Wubin MaHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Yiren HuHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Bogdan TanasaStanford University School of Medicine, 265 Campus Drive, LLSCR Building, Stanford, CA 94305, USA.
Soohwan OhHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Biological Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
Amir GamlielHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Qi MaHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
Lu YaoHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Breast Center, Peking University Cancer Hospital and Institute, Beijing 100142, China.
Jie ZhangHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Kenny OhgiHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Wen LiuHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Aneel K AggarwalDepartment of Structural and Chemical Biology, Mount Sinai School of Medicine, Box 1677, 1425 Madison Avenue, New York, NY 10029, USA.
Michael G RosenfeldHoward Hughes Medical Institute, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: mrosenfeld@ucsd.edu.
Howard Hughes Medical Institute · USUniversity of California, San Diego · USIcahn School of Medicine at Mount Sinai · USStanford University · USXiamen University · CN
Funding
HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSIONR01DK018477 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 1986 to 2025
$12.7MREGULATION OF NEUROENDOCRINE SWITCHING EVENTSR37DK039949 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 1987 to 2020
$12.3MLigand Regulated Epigenetic/Nuclear Architectural Strategies and Human DiseaseR01NS034934 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 1995 to 2013
$6.8MEnhancer TherapyR01CA173903 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASS, CHRISTOPHER K · 2012 to 2016
$6.3MEXPERIMENTAL ENDOCRINOLOGY AND METABOLISMT32DK007044 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Amit Majithia · 1986 to 2026
$4.6MREGULATION OF NEUROENDOCRINE SWITCHING EVENTSR01DK039949 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 1996 to 2024
$2.4MRepressive Transcriptional Programs in Breast CancerR01CA213371 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 2017 to 2021
$755kHoward Hughes Medical InstituteNCI NIH HHS R01 CA173903NCI NIH HHS R01 CA213371NIDDK NIH HHS R01 DK018477NIDDK NIH HHS R01 DK039949NIDDK NIH HHS R37 DK039949NIDDK NIH HHS T32 DK007044NINDS NIH HHS R01 NS034934
Abstract
Nuclear receptors induce both transcriptional activation and repression programs responsible for development, homeostasis, and disease. Here, we report a previously overlooked enhancer decommissioning strategy underlying a large estrogen receptor alpha (ERα)-dependent transcriptional repression program. The unexpected signature for this E
Indexed as
Enhancer Elements, GeneticBase SequenceBinding SitesCRISPR-Cas SystemsEstradiolEstrogen Receptor alphaF-Box ProteinsGene EditingGene Expression RegulationHEK293 CellsHepatocyte Nuclear Factor 3-alphaHistonesHumansJumonji Domain-Containing Histone DemethylasesMCF-7 CellsNedd4 Ubiquitin Protein LigasesESR1 protein, humanEstradiolEstrogen Receptor alphaF-Box ProteinsFOXA1 protein, humanHepatocyte Nuclear Factor 3-alphaHistonesJumonji Domain-Containing Histone DemethylasesKDM2A protein, humanNedd4 protein, humanNedd4 Ubiquitin Protein LigasesRNARNA Polymerase IIdecommissionenhancereRNAERαKDM2ANEDD4nuclear receptorPol IIrepressiontranscription
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.