Observational studyPloS one2018
Predicting acute renal failure in Bothrops snakebite patients in a tertiary reference center, Western Brazilian Amazon.
Observational study in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Snake envenomation and acute kidney injury: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- Outcomes Associated With the Timing of Antivenom Administration in Bothrops and Crotalus Snakebite Envenomations.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
- Snakebite Envenomations In The Brazilian Amazon: A Little Less Neglected.Revista da Sociedade Brasileira de Medicina Tropical · 2026Review
- Acute kidney injury induced by snakebites in pediatric patients.Pediatric nephrology (Berlin, Germany) · 2025Article
- Masked peril: acute kidney injury in snakebite victims.Pediatric nephrology (Berlin, Germany) · 2025Article
- Decentralization of snakebite antivenom treatment to indigenous community health centers in the Brazilian Amazon: From demand to the first treatment (the SAVING Program).PLoS neglected tropical diseases · 2025Article
- Dermatopathological findings of Bothrops atrox snakebites: A case series in the Brazilian Amazon.PLoS neglected tropical diseases · 2024Article
- Predicting pre- and post-operative acute kidney injury in elderly patients with coronary artery disease.Heliyon · 2024Article
- Urinary proteomics reveals biological processes related to acute kidney injury in Bothrops atrox envenomings.PLoS neglected tropical diseases · 2024Article
- Compendium of medically important snakes, venom activity and clinical presentations in Ghana.PLoS neglected tropical diseases · 2023Article
- Effect of the time to antivenom administration on recovery from snakebite envenoming-related coagulopathy in French Guiana.PLoS neglected tropical diseases · 2023Observational
- Article
- Mapping of clinical management resources for snakebites and other animal envenomings in the Brazilian Amazon.Toxicon: X · 2022Article
- Review of the Mechanisms of Snake Venom Induced Pain: It's All about Location, Location, Location.International journal of molecular sciences · 2022Review
- Managing snakebite.BMJ (Clinical research ed.) · 2022Review
- Secondary infection profile after snakebite treated at a tertiary referral center in the Brazilian Amazon.Revista da Sociedade Brasileira de Medicina Tropical · 2022Article
- CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after aMediators of inflammation · 2022Article
- Snake bite associated with acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2021Review
- Observation ofToxins · 2021Article
- Bleeding and Thrombosis: Insights into Pathophysiology ofInternational journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute Kidney Injury (AKI) is the main systemic complication and cause of death in viperid envenomation. Although there are hypotheses for the development of AKI, the mechanisms involved are still not established. The aim of this study was to evaluate the clinical-laboratorial-epidemiological factors associated with AKI in victims of Bothrops sp envenomation. This is an observational study carried out at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. AKI was defined according to the guidelines of the Acute Kidney Injury Network (AKIN). Among the 186 patients evaluated, AKI was observed in 24 (12.9%) after 48 hours of admission. Stage I was present in 17 (70.8%) patients, II in 3 (12.5%) and III in 4 (16.7%). Epidemiological characterization showed predominance of men, occurrence in rural areas, aged between 16-60 years, feet as the most affected anatomical region, and time to medical assistance less than 3 hours. Hypertension and diabetes were the comorbidities identified. Most of the accidents were classified as moderate, and clinical manifestations included severe pain, mild edema, local bleeding and headache. Laboratory results showed blood uncoagulability, hypofibrinogenemia, leukocytosis, increase of creatine kinase, and high lactate dehydrogenase levels. Multivariate analysis showed an association with high LDH levels [AOR = 1.01 (95% CI = 1.01-1.01, p<0.002)], local bleeding [AOR = 0.13 (95%CI = 0.027-0.59, p<0.009)], and the presence of comorbidities [AOR = 60.96 (95%CI = 9.69-383.30; p<0.000)]. Herein, laboratory markers such as high LDH levels along with local bleeding and comorbidities may aid in the diagnosis of AKI.
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