ArticlePhysiological genomics2018
Effects of placental growth factor deficiency on behavior, neuroanatomy, and cerebrovasculature of mice.
Article in Physiological genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Maternal Apocynin During Experimental Preeclampsia Prevents BBB Permeability and Increased Vascular Tone of Cerebral Arteries in Male but Not Female Rat Adult Offspring.Microcirculation (New York, N.Y. : 1994) · 2026Article
- The relationship between folic acid deficiency and preeclampsia-like phenotypes in rats.BMC pregnancy and childbirth · 2025Article
- Neurodevelopmental Disruptions in Children of Preeclamptic Mothers: Pathophysiological Mechanisms and Consequences.International journal of molecular sciences · 2024Review
- The role of the placenta-brain axis in psychoneuroimmune programming.Brain, behavior, & immunity - health · 2024Article
- Reduced Brain Cortex Angiogenesis in the Offspring of the Preeclampsia-Like Syndrome.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone-induced intrauterine growth restriction.Brain pathology (Zurich, Switzerland) · 2021Article
- Cardiovascular and Cerebrovascular Implications of Growth Restriction: Mechanisms and Potential Treatments.International journal of molecular sciences · 2021Review
- Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model.Translational psychiatry · 2021Article
- Shared Genetic Liability and Causal Associations Between Major Depressive Disorder and Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2021Article
- A Longitudinal Pilot Study on Cognition and Cerebral Hemodynamics in a Mouse Model of Preeclampsia Superimposed on Hypertension: Looking at Mothers and Their Offspring.Frontiers in physiology · 2021Article
- Pre-eclampsia Complicated With Maternal Renal Dysfunction Is Associated With Poor Neurological Development at 3 Years Old in Children Born Before 34 Weeks of Gestation.Frontiers in pediatrics · 2021Article
- Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure.Trends in neurosciences · 2020Review
- Oligodendrocytes Death Induced Sensorimotor and Cognitive Deficit in N-nitro-L-arginine methyl Rat Model of Pre-eclampsia.Neurochemical research · 2020Article
- Adult PgfScientific reports · 2019Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia, a hypertensive syndrome occurring in 3-5% of human pregnancies, has lifelong health consequences for fetuses. Cognitive ability throughout life is altered, and adult stroke risk is increased. One potential etiological factor for altered brain development is low concentrations of proangiogenic placental growth factor (PGF). Impaired PGF production may promote an antiangiogenic fetal environment during neural and cerebrovascular development. We previously reported delayed vascularization of the hindbrain, altered retinal vascular organization, and less connectivity in the circle of Willis in Pgf
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.