Evidence map›Paper›PMID 30118345›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2018

Attenuated forearm vascular conductance responses to rhythmic handgrip in young African-American compared with Caucasian-American men.

Thales C Barbosa, Jasdeep Kaur, Brandi Y Stephens, John D Akins, David M Keller, R Matthew Brothers, Paul J Fadel

Registry-linked trialOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04770155 (Vascular Dysfunction in Black Individuals), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04770155 early_phase1terminatednot on this mapstarted 2021, after this paper: background citation

Vascular Dysfunction in Black Individuals: Roles of Nitric Oxide and Endothelin-1

TypeinterventionalSponsorUniversity of Mississippi Medical CenterRan2021 to 2021Enrolled8ConditionsVascular Function, Racial DisparityArmsDietary Nitrates 400 mg, L-citrulline 3 g, Sildenafil 100 mg, Bosentan 125 mg
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Race and sex differences in cardiovascular autonomic regulation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
    Review
  6. Functional sympatholysis is preserved in healthy young Black men during rhythmic handgrip exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  7. Article
  8. Neural control of cardiovascular function in black adults: implications for racial differences in autonomic regulation.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Review
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Thales C BarbosaDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington , Arlington, Texas.ORCID 0000-0001-5776-3824
Jasdeep KaurDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington , Arlington, Texas.
Brandi Y StephensDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington , Arlington, Texas.
John D AkinsDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington , Arlington, Texas.
David M KellerDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington , Arlington, Texas.
R Matthew BrothersDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington , Arlington, Texas.
Paul J FadelDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington , Arlington, Texas.
The University of Texas at Arlington · US

Funding

Targeting Sympathetic Overactivity in CKD patients: Mechanisms & Novel TherapiesR01HL127071 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI FADEL, PAUL J · 2016 to 2019
$1.7M
Sympathetic baroreflex control and vascular transduction in African AmericansR15HL130906 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI KELLER, DAVID M · 2016 to 2016
$377k
NHLBI NIH HHS R15 HL130906
6 · The paper itself

Abstract

Previous studies have demonstrated that African-American (AA) individuals have heightened vasoconstrictor and reduced vasodilator responses under resting conditions compared with Caucasian-American (CA) individuals. However, potential differences in vascular responses to exercise remain unclear. Therefore, we tested the hypothesis that, compared with CA subjects, AA subjects would present an attenuated increase in forearm vascular conductance (FVC) during rhythmic handgrip exercise. Forearm blood flow (FBF; duplex Doppler ultrasound) and mean arterial pressure (MAP; finger photoplethysmography) were measured in healthy young CA ( n = 10) and AA ( n = 10) men during six trials of rhythmic handgrip performed at workloads of 4, 8, 12, 16, 20, and 24 kg. FVC (calculated as FBF/MAP), FBF, and MAP were similar between groups at rest (FVC: 63 ± 7 ml·min

Indexed as

Black or African AmericanHand StrengthHemodynamicsMuscle ContractionWhite PeopleAge FactorsBlood Flow VelocityBrachial ArteryExerciseForearmHumansHyperemiaMaleMuscle, SkeletalRegional Blood FlowSex Factorsblackblood velocitybrachial arterydiameterdynamic exerciseracial differenceswhite

Identifiers

PMID30118345
PMCPMC6297811
OpenAlexW2886819577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.