Evidence map›Paper›PMID 30117808›Full record

ArticleeLife2018

Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the

Erez Cohen, Scott R Allen, Jessica K Sawyer, Donald T Fox

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 103 citations in OpenAlex.

  1. Growth under pressure: The pros and cons of polyploidy induced by stress.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Review
  2. Epithelial cell fusion is required for tissue repair following UV-A irradiation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  12. Identification and characterization of planarian multinucleated cells inFrontiers in cell and developmental biology · 2025
    Article
  13. Article
  14. Hallmarks of regeneration.Cell stem cell · 2024
    Review
  15. Article
  16. Cell cycle re-entry in the agingbioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Erez CohenDepartment of Cell Biology, Duke University School of Medicine, Durham, United States.ORCID http://orcid.org/0000-0003-2390-3707
Scott R AllenDepartment of Cell Biology, Duke University School of Medicine, Durham, United States.ORCID http://orcid.org/0000-0002-4809-0493
Jessica K SawyerDepartment of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, United States.
Donald T FoxDepartment of Cell Biology, Duke University School of Medicine, Durham, United States.ORCID http://orcid.org/0000-0002-0436-179X
Duke University · US

Funding

ORGANIZATION AND FUNCTIONS OF CELLULAR STRUCTUREST32GM007184 · NIGMS · DUKE UNIVERSITY · PI JINKS-ROBERTSON, SUE · 1985 to 2019
$18.2M
Polyploidy after tissue injury: a Drosophila modelR01GM118447 · NIGMS · DUKE UNIVERSITY · PI FOX, DONALD T. · 2016 to 2025
$3.1M
Examining infection-mediated metastasis with single-cell resolutionF32GM109538 · NIGMS · DUKE UNIVERSITY · PI SAWYER, JESSICA KIMBERLEY · 2014 to 2015
$113k
NIGMS NIH HHS F32 GM109538NIGMS NIH HHS R01 GM118447NIGMS NIH HHS T32 GM007184NIH HHS GM118447
6 · The paper itself

Abstract

Ploidy-increasing cell cycles drive tissue growth in many developing organs. Such cycles, including endocycles, are increasingly appreciated to drive tissue growth following injury or activated growth signaling in mature organs. In these organs, the regulation and distinct roles of different cell cycles remains unclear. Here, we uncover a programmed switch between cell cycles in the

Indexed as

AnimalsCdh1 ProteinsCell CycleCell Cycle ProteinsDigestive SystemDrosophila melanogasterDrosophila ProteinsGastric MucosaGene Expression Regulation, DevelopmentalLarvaMitosisSignal TransductionCdh1 ProteinsCell Cycle ProteinsDrosophila Proteinsfzr protein, Drosophiladevelopmental biologyD. melanogasterendocycleendoreplicationtissue injury

Identifiers

PMID30117808
PMCPMC6130973
OpenAlexW2886455231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.