Evidence map›Paper›PMID 30117766›Full record

ArticleJournal of neurosurgery2019

Long-term outcomes among octogenarians with aneurysmal subarachnoid hemorrhage.

Hormuzdiyar Dasenbrock, William B Gormley, Yoojin Lee, Vincent Mor, Susan L Mitchell, Corey R Fehnel

Open access · bronzeAbstract read
In one paragraph

Article in Journal of neurosurgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hormuzdiyar Dasenbrock1Department of Neurosurgery, Brigham and Women's Hospital.
William B Gormley1Department of Neurosurgery, Brigham and Women's Hospital.
Yoojin Lee3Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, Rhode Island.
Vincent Mor3Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, Rhode Island.
Susan L Mitchell2Harvard Medical School.
Corey R Fehnel2Harvard Medical School.
Brigham and Women's Hospital · USHarvard University · USBrown University · US

Funding

Prescribing cascades in older adults with and without dementiaK24AG049057 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEINMAN, MICHAEL A. · 2015 to 2025
$1.8M
Midcareer Mentoring Award for Patient-Oriented Research in AgingK24AG033640 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI MITCHELL, SUSAN L · 2009 to 2018
$1.8M
Outcomes of beta blockers after myocardial infarction in nursing home residentsR01HL111032 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI STEINMAN, MICHAEL A. · 2012 to 2014
$1.7M
NHLBI NIH HHS R01 HL111032NIA NIH HHS K24 AG033640NIA NIH HHS K24 AG049057
6 · The paper itself

Abstract

objectiveData evaluating the long-term outcomes, particularly with regard to treatment modality, of aneurysmal subarachnoid hemorrhage (SAH) in octogenarians are limited. The primary objectives were to evaluate the disposition (living at home vs institutional settings) and analyze the predictors of long-term survival and return to home for octogenarians after SAH.

methodsData pertaining to patients age 80 and older who underwent microsurgical clipping or endovascular coiling for SAH were extracted from 100% nationwide Medicare inpatient claims and linked with the Minimum Data Set (2008-2011). Patient disposition was tracked for 2 years after index SAH admission. Multivariable logistic regression stratified by aneurysm treatment modality, and adjusted for patient factors including SAH severity, evaluated predictors of return to home at 60 and 365 days after SAH. Survival 365 days after SAH was analyzed with a multivariable Cox proportional hazards model.

resultsA total of 1298 cases were included in the analysis. One year following SAH, 56% of the patients had died or were in hospice care, 8% were in an institutional post-acute care setting, and 36% had returned home. Open microsurgical clipping (adjusted hazard ratio [aHR] 0.67, 95% confidence interval [CI] 0.54-0.81), male sex (aHR 0.70, 95% CI 0.57-0.87), tracheostomy (aHR 0.63, 95% CI 0.47-0.85), gastrostomy (aHR 0.60, 95% CI 0.48-0.76), and worse SAH severity (aHR 0.94, 95% CI 0.92-0.97) were associated with reduced likelihood of patients ever returning home. Older age (aHR 1.09, 95% CI 1.05-1.13), tracheostomy (aHR 2.06, 95% CI 1.46-2.91), gastrostomy (aHR 1.55, 95% CI 1.14-2.10), male sex (aHR 1.66, 95% CI 1.20-2.23), and worse SAH severity 1.51 (95% CI 1.04-2.18) were associated with reduced survival.

conclusionsIn this national analysis, 56% of octogenarians with SAH died, and 36% returned home within 1 year of SAH. Coil embolization predicted returning to home, which may suggest a benefit to endovascular treatment in this patient population.

Indexed as

Aged, 80 and overEndovascular ProceduresFee-for-Service PlansFemaleHumansMaleMedicareMicrosurgerySubarachnoid HemorrhageSurvival RateTime FactorsTreatment OutcomeUnited StatesageaHR = adjusted hazard ratiocerebral aneurysmCI = confidence intervalclippingCMS = Centers for Medicare & Medicaid ServicesendovascularICD-9-CM = International Classification of Diseases, 9th Revision, Clinical Modificationlong-term outcomesMedicareMinimum Data SetNIS = Nationwide Inpatient SampleNIS-SSS = NIS SAH Severity ScoreoctogenariansSAH = subarachnoid hemorrhagesubarachnoid hemorrhagevascular disorders

Identifiers

PMID30117766
PMCPMC6358513
OpenAlexW2886363535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.