Evidence map›Paper›PMID 30117681›Full record

ArticleJournal of cellular and molecular medicine2018

Signalling mechanisms that regulate metabolic profile and autophagy of acute myeloid leukaemia cells.

Olga Pereira, Alexandra Teixeira, Belém Sampaio-Marques, Isabel Castro, Henrique Girão, Paula Ludovico

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Review
  4. Review
  5. Review
  6. A Leukemic Target with a Thousand Faces: The Mitochondria.International journal of molecular sciences · 2023
    Review
  7. Article
  8. The dual role of autophagy in acute myeloid leukemia.Journal of hematology & oncology · 2022
    Review
  9. Article
  10. Autophagy and Metabolism in Normal and Malignant Hematopoiesis.International journal of molecular sciences · 2021
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Olga PereiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Alexandra TeixeiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Belém Sampaio-MarquesLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Isabel CastroLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Henrique GirãoInstitute for Biomedical Imaging and Life Science (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Paula LudovicoLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.ORCID 0000-0003-4130-7167
University of Minho · PTAssociation for Innovation and Biomedical Research on Light and Image · PT

Funding

Optical Imaging of Breast CancerR01CA090533 · NCI · UNIVERSITY OF FLORIDA · PI JIANG, HUABEI · 2002 to 2006
$1.4M
6 · The paper itself

Abstract

Acute myeloid leukaemia (AML) comprises a heterogeneous group of hematologic neoplasms characterized by diverse combinations of genetic, phenotypic and clinical features representing a major challenge for the development of targeted therapies. Metabolic reprogramming, mainly driven by deregulation of the nutrient-sensing pathways as AMPK, mTOR and PI3K/AKT, has been associated with cancer cells, including AML cells, survival and proliferation. Nevertheless, the role of these metabolic adaptations on the AML pathogenesis is still controversial. In this work, the metabolic status and the respective metabolic networks operating in different AML cells (NB-4, HL-60 and KG-1) and their impact on autophagy and survival was characterized. Data show that whereas KG-1 cells exhibited preferential mitochondrial oxidative phosphorylation metabolism with constitutive co-activation of AMPK and mTORC1 associated with increased autophagy, NB-4 and HL-60 cells displayed a dependent glycolytic profile mainly associated with AKT/mTORC1 activation and low autophagy flux. Inhibition of AKT is disclosed as a promising therapeutical target in some scenarios while inhibition of AMPK and mTORC1 has no major impact on KG-1 cells' survival. The results highlight an exclusive metabolic profile for each tested AML cells and its impact on determination of the anti-leukaemia efficacy and on personalized combinatory therapy with conventional and targeted agents.

Indexed as

AMP-Activated Protein Kinase KinasesAutophagyEnergy MetabolismGlycolysisHL-60 CellsHumansLeukemia, Myeloid, AcuteMechanistic Target of Rapamycin Complex 1MetabolomeMitochondriaMolecular Targeted TherapyOncogene Protein v-aktOxidative PhosphorylationPhosphatidylinositol 3-KinasesPhosphorylationProtein KinasesAMP-Activated Protein Kinase KinasesMechanistic Target of Rapamycin Complex 1MTOR protein, humanOncogene Protein v-aktPhosphatidylinositol 3-KinasesProtein KinasesTOR Serine-Threonine Kinasesacute myeloid leukaemiaautophagyenergetic metabolismglycolysismitochondrial oxidative phosphorylationnutrient-sensing pathways

Identifiers

PMID30117681
PMCPMC6156238
OpenAlexW2887653605

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.