ArticlePlant biotechnology journal2019
An Arabidopsis E3 ligase HUB2 increases histone H2B monoubiquitination and enhances drought tolerance in transgenic cotton.
Article in Plant biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39 citing papers in PubMed, 81 citations in OpenAlex.
- Carbon Dioxide Enrichment Partially Alleviates the Impact of Drought Stress on Cotton Growth and Yield.Plants (Basel, Switzerland) · 2026Article
- HUB1 positively regulates salt tolerance in Arabidopsis through dynamic H2B monoubiquitination.Plant cell reports · 2026Article
- New insights into controlling horticultural crop quality deterioration caused by cold stress: epigenetic modification.Horticulture research · 2026Article
- Rhythmic Mechanisms Governing CAM Photosynthesis inInternational journal of molecular sciences · 2026Article
- Conservation and divergence of abiotic stress-responsive gene co-expression networks in diploid and tetraploid cotton.Frontiers in plant science · 2026Article
- Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation.bioRxiv : the preprint server for biology · 2025Article
- Protein networks: integrating pathways for plant heat stress adaptation.Functional & integrative genomics · 2025Review
- Gaining insights into epigenetic memories through artificial intelligence and omics science in plants.Journal of integrative plant biology · 2025Review
- Transcriptome profiling reveals key genes in eggplant (Solanum melongena) roots under salt stress.BMC genomics · 2025Article
- B4 Raf-like MAPKKK RAF24 regulates Arabidopsis thaliana flowering time through HISTONE MONO-UBIQUITINATION 2.The New phytologist · 2025Article
- Review
- A review on strategies for crop improvement against drought stress through molecular insights.3 Biotech · 2024Review
- Advanced Biotechnological Interventions in Mitigating Drought Stress in Plants.Plants (Basel, Switzerland) · 2024Review
- To live or let die? Epigenetic adaptations to climate change-a review.Environmental epigenetics · 2024Review
- Multi-omics analysis of hexaploid triticale that show molecular responses to salt stress during seed germination.Frontiers in plant science · 2024Article
- Role of Epigenetic Factors in Response to Stress and Establishment of Somatic Memory of Stress Exposure in Plants.Plants (Basel, Switzerland) · 2023Review
- Plant Tolerance to Drought Stress with Emphasis on Wheat.Plants (Basel, Switzerland) · 2023Review
- MMR Deficiency Defines Distinct Molecular Subtype of Breast Cancer with Histone Proteomic Networks.International journal of molecular sciences · 2023Article
- Methylation hallmarks on the histone tail as a linker of osmotic stress and gene transcription.Frontiers in plant science · 2022Review
- An Epigenetic Alphabet of Crop Adaptation to Climate Change.Frontiers in genetics · 2022Review
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
The HUB2 gene encoding histone H2B monoubiquitination E3 ligase is involved in seed dormancy, flowering timing, defence response and salt stress regulation in Arabidopsis thaliana. In this study, we used the cauliflower mosaic virus (CaMV) 35S promoter to drive AtHUB2 overexpression in cotton and found that it can significantly improve the agricultural traits of transgenic cotton plants under drought stress conditions, including increasing the fruit branch number, boll number, and boll-setting rate and decreasing the boll abscission rate. In addition, survival and soluble sugar, proline and leaf relative water contents were increased in transgenic cotton plants after drought stress treatment. In contrast, RNAi knockdown of GhHUB2 genes reduced the drought resistance of transgenic cotton plants. AtHUB2 overexpression increased the global H2B monoubiquitination (H2Bub1) level through a direct interaction with GhH2B1 and up-regulated the expression of drought-related genes in transgenic cotton plants. Furthermore, we found a significant increase in H3K4me3 at the DREB locus in transgenic cotton, although no change in H3K4me3 was identified at the global level. These results demonstrated that AtHUB2 overexpression changed H2Bub1 and H3K4me3 levels at the GhDREB chromatin locus, leading the GhDREB gene to respond quickly to drought stress to improve transgenic cotton drought resistance, but had no influence on transgenic cotton development under normal growth conditions. Our findings also provide a useful route for breeding drought-resistant transgenic plants.
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