Evidence map›Paper›PMID 30117062›Full record

ArticleEJNMMI research2018

Anti PD-1 treatment increases [

Mayu Tomita, Hironobu Yasui, Kei Higashikawa, Kohei Nakajima, Hideo Takakura, Tohru Shiga, Yuji Kuge, Mikako Ogawa

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Fuel for thought: targeting metabolism in lung cancer.Translational lung cancer research · 2024
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  5. Localized ablative immunotherapy drives de novo CD8Journal for immunotherapy of cancer · 2022
    Article
  6. Review
  7. Article
  8. Assessing immune organs onEuropean journal of nuclear medicine and molecular imaging · 2021
    Observational
  9. Review
  10. Potentials of Non-InvasiveFrontiers in genetics · 2021
    Review
  11. Article
  12. Influence on [EJNMMI research · 2020
    Article
  13. Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis withInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2019
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mayu TomitaLaboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, 060-0812, Japan.
Hironobu YasuiCentral Institute of Isotope Science, Hokkaido University, Sapporo, Japan.
Kei HigashikawaCentral Institute of Isotope Science, Hokkaido University, Sapporo, Japan.
Kohei NakajimaLaboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, 060-0812, Japan.
Hideo TakakuraLaboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, 060-0812, Japan.
Tohru ShigaGraduate School of Medicine, Hokkaido University, Sapporo, Japan.
Yuji KugeCentral Institute of Isotope Science, Hokkaido University, Sapporo, Japan.
Mikako OgawaLaboratory of Bioanalysis and Molecular Imaging, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, 060-0812, Japan. mogawa@pharm.hokudai.ac.jp.ORCID http://orcid.org/0000-0002-3432-4519
Hokkaido University · JPHokkaido University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProgrammed cell death 1 (PD-1) inhibitors act as immune checkpoint inhibitors and are more effective for improving survival time with less toxicity as compared with conventional chemotherapies. In anti PD-1 therapy, it is important to evaluate metabolism in the cancer microenvironment, as this helps to clarify the pathological conditions. Herein, we investigate the early effects of PD-1 therapy on 2-deoxy-2-[

resultsIn a B16F10 melanoma model, [

conclusionThe present study shows that anti PD-1 therapy increases glucose metabolism in cancer cells.

Indexed as

[18F]FDGImmune checkpoint inhibitorMouse melanomaPD-1Tumor microenvironment

Identifiers

PMID30117062
PMCPMC6095935
OpenAlexW2887388774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.