SynthesisDrug safety2019
The Prevalence of Dose Errors Among Paediatric Patients in Hospital Wards with and without Health Information Technology: A Systematic Review and Meta-Analysis.
Synthesis in Drug safety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Use of Computerized Physician Order Entry with Clinical Decision Support to Prevent Dose Errors in Pediatric Medication Orders: A Systematic Review.Paediatric drugs · 2024Pooled it
- Identifying the data elements and functionalities of clinical decision support systems to administer medication for neonates and pediatrics: a systematic literature review.BMC medical informatics and decision making · 2023Pooled it
- Effectiveness of non-interruptive nudge interventions in electronic health records to improve the delivery of care in hospitals: a systematic review.Journal of the American Medical Informatics Association : JAMIA · 2023Pooled it
- Interventions to Reduce Pediatric Prescribing Errors in Professional Healthcare Settings: A Systematic Review of the Last Decade.Paediatric drugs · 2021Pooled it
- How effective are electronic medication systems in reducing medication error rates and associated harm among hospital inpatients? A systematic review and meta-analysis.Journal of the American Medical Informatics Association : JAMIA · 2021Pooled it
- Interventions to Reduce Medication Dispensing, Administration, and Monitoring Errors in Pediatric Professional Healthcare Settings: A Systematic Review.Frontiers in pediatrics · 2021Pooled it
- Prevalence and Nature of Medication Errors and Preventable Adverse Drug Events in Paediatric and Neonatal Intensive Care Settings: A Systematic Review.Drug safety · 2019Pooled it
- Prevalence of Medication Errors Among Paediatric Inpatients: Systematic Review and Meta-Analysis.Drug safety · 2019Pooled it
- Impact of a clinical decision support system on paediatric drug dose prescribing: a randomised within-subject simulation trial.BMJ paediatrics open · 2023Trial
- Development of a minimum data set for a pediatric and neonatal Medication Administration Clinical Decision Support System (MACDSS), mapped to FHIR: a mixed-methods research synthesis.BMC medical informatics and decision making · 2026Article
- Preventing Medication Errors in Paediatrics: A Narrative Review.Clinical medicine insights. Pediatrics · 2026Review
- Prevalence and types of medication errors among children under five (5) years in 3 primary health care facilities in the Western region of Ghana: a retrospective quantitative study.BMC primary care · 2025Article
- Evaluation of the Use of a Novel Intelligent Diagnosis and Cost Control System on Pediatric Bronchopneumonia Outcomes: Retrospective Cohort Study.JMIR pediatrics and parenting · 2025Article
- Article
- Prescribing errors in children: what is the impact of a computerized physician order entry?European journal of pediatrics · 2023Article
- Improving medication safety in a paediatric hospital: a mixed-methods evaluation of a newly implemented computerised provider order entry system.BMJ health & care informatics · 2023Observational
- Short- and long-term effects of an electronic medication management system on paediatric prescribing errors.NPJ digital medicine · 2022Article
- Description of a clinical decision support tool with integrated dose calculator for paediatrics.European journal of pediatrics · 2022Article
- Physicians' perspectives on adverse drug reactions in pediatric routine care: a survey.World journal of pediatrics : WJP · 2022Article
- Patient-held health IT adoption across the primary-secondary care interface: a Normalisation Process Theory perspective.Health systems (Basingstoke, England) · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe risk of dose errors is high in paediatric inpatient settings. Computerized provider order entry (CPOE) systems with clinical decision support (CDS) may assist in reducing the risk of dosing errors. Although a frequent type of medication error, the prevalence of dose errors is not well described. Dosing error rates in hospitals with or without CPOE have not been compared.
objectiveOur aim was to conduct a systematic review assessing the prevalence and impact of dose errors in paediatric wards with and without CPOE and/or CDS.
methodsWe systematically searched five databases to identify studies published between January 2000 and December 2017 that assessed dose error rates by medication chart audit or direct observation.
resultsWe identified 39 studies, nine of which involved paediatric wards using CPOE with or without CDS. Studies of paediatric wards using paper medication charts reported approximately 8-25% of patients experiencing a dose error, and approximately 2-6% of medication orders and approximately 3-8% of dose administrations contained a dose error, with estimates varying by ward type. The nine studies of paediatric wards using CPOE reported approximately 22% of patients experiencing a dose error, and approximately 1-6% of medication orders and approximately 3-8% of dose administrations contained a dose error. Few studies provided data for individual wards. The severity and prevalence of harm associated with dose errors was rarely assessed and showed inconsistent results.
conclusionsDose errors occur in approximately 1 in 20 medication orders. Hospitals using CPOE with or without CDS had a lower rate of dose errors compared with those using paper charts. However, few pre/post studies have been conducted and none reported a significant reduction in dose error rates associated with the introduction of CPOE. Future research employing controlled designs is needed to determine the true impact of CPOE on dosing errors among children, and any associated patient harm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.