Evidence map›Paper›PMID 30117019›Full record

ReviewDrugs2018

Perioperative Use of Intravenous Lidocaine.

Marc Beaussier, Alain Delbos, Axel Maurice-Szamburski, Claude Ecoffey, Luc Mercadal

7 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 122 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 6 pooled it
41.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04741880 phase2 / phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs

TypeinterventionalSponsorInstituto Nacional de Cancer, BrazilRan2021 to 2023Enrolled66ConditionsAnesthesia, CancerArmsLidocaine IV, Saline
NCT05044429 phase4terminatednot on this mapstarted 2021, after this paper: background citation

Postoperative Pain Control With Systemic Lidocaine vs. Regional Anesthesia in Renal Transplant Patients

TypeinterventionalSponsorGeorge Washington UniversityRan2021 to 2023Enrolled31ConditionsKidney Transplant, Complications, Pain, PostoperativeArmsIntravenous Lidocaine, Transversus abdominis plane (TAP) block, Quadratus Lumborum (QL) Block
NCT05153785 phase2 / phase3completednot on this mapstarted 2021, after this paper: background citation

Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study

TypeinterventionalSponsorLund University HospitalRan2021 to 2025Enrolled124ConditionsLiver Metastases, Liver Cancer, Postoperative Pain, Opioid UseArmsLidocaine, Normal saline
NCT06249113 nacompletednot on this mapstarted 2023, after this paper: background citation

Effectiveness of Adjuvant Continuous Lidocaine in General Anesthesia on Depth of Anesthesia (qCON), Pain Response (qNOX), and Blood Sugar Levels in Elective Primary Tumor Craniotomy Surgery

TypeinterventionalSponsorIndonesia UniversityRan2023 to 2024Enrolled60ConditionsSurgery, Anesthesia, Functional, Haemodynamic InstabilityArmsNaCl 0.9%, Adjuvant lidocaine continous
NCT06457100 phase1 / phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

Comparison of the Effects of Perioperative Intravenous Infusions of Esmolol and Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery:A Randomized, Non-inferiority Trial

TypeinterventionalSponsorThe Second People's Hospital of Huai'anRan2023 to 2024Enrolled60ConditionsChronic Rhinosinusitis, Enhanced Recovery After SurgeryArmsEsmolol Injection, Lidocaine IV
NCT06785987 phase4enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Continuous Lidocaine Infusion in Thyroid Surgery Using Intraoperative Neurophysiological Monitoring

TypeinterventionalSponsorKaohsiung Veterans General Hospital.Ran2024 to 2027Enrolled100ConditionsThyroid Disease, Thyroid Surgery, Lidocaine InfusionArmsContinuous Lidocaine Infusion, intermittent fentanyl infusion, Continuous remifentanil Infusion
NCT07073846 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Lidocaine-Dexmedetomidine Combination Therapy in Reducing Post-Operative Pain, Inflammatory Response, and Oxidative Stress in Patients Undergoing Bariatric Surgery

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2025 to 2027Enrolled104ConditionsMorbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management, Postoperative AnalgesiaArmsIntravenous Lidocaine infusion + Standard Anesthesia, Intravenous Dexmedetomidine infusion + Standard Anesthesia, Lidocaine + Dexmedetomidine Combination (LIDEX) + Standard Anesthesia, 0.9 % Saline Placebo + Standard Anesthesia
3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 6 syntheses or guidelines pooled it, 377 citations in OpenAlex.

  1. Pooled it
  2. Efficacy of perioperative lidocaine infusion on surgical field quality during functional endoscopic sinus surgery: a systematic review and meta-analysis with trial sequential analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Marc BeaussierDepartment of Anaesthesiology, Institut Mutualiste Montsouris, 42 Bd Jourdan, 75014, Paris, France. marc.beaussier@imm.fr.ORCID http://orcid.org/0000-0002-5304-6542
Alain DelbosClinique Medipole Garonne, Toulouse, France.
Axel Maurice-SzamburskiClinique Juge, Marseille, France.
Claude EcoffeyHôpital Pontchaillou, Université Rennes 1, Rennes Cedex 9, France.
Luc MercadalHôpital Claude Galien, 91480, Quincy-Sous-Sénart, France.
Hôpital Pontchaillou · FRInstitute Mutualiste Montsouris · FRMédipole Garonne · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lidocaine is an amide local anaesthetic initially used intravenously as an antiarrhythmic agent. At some point it was proposed that intravenous lidocaine (IVL) had an analgesic effect that could be potentially beneficial in perioperative settings. Since these preliminary reports, a large body of evidence confirmed that IVL had anti-inflammatory and opiate-sparing effects, a combination of characteristics leading to an array of effects such as a decrease in postoperative pain and opiate consumption, and a reduction in the duration of digestive ileus. Additional studies demonstrated IVL to possess antithrombotic, antimicrobial and antitumoral effects. Beneficial effects of IVL have been characterized in abdominal surgery but remain controversial in other types of surgeries. Because the quality of evidence was limited, due to inconsistency, imprecision and study quality, recent conclusions from meta-analysis pooling together all types of surgery stated the uncertainty about IVL benefits. Additional indications such as the prevention of propofol-induced injection pain, prevention of hyperalgesia, protection against bronchial reactivity by bronchotracheal relaxation during surgery, and the increase in depth of general anaesthesia have since emerged. IVL is rapidly distributed in the body and metabolized by the liver. With the commonly recommended doses, lidocaine's therapeutic index remains very high and the plasma concentrations stay largely below the cardiotoxic and neurotoxic threshold levels, a notion that may be used by clinicians to draw conclusions on the benefit-risk profile of IVL in comparison to other analgesic strategies. The purpose of this review is to address the pharmacokinetic and pharmacodynamic properties of lidocaine in healthy and pathological conditions.

Indexed as

Administration, IntravenousAnalgesicsAnalgesics, OpioidAnesthetics, LocalAnimalsHumansHyperalgesiaLidocainePerioperative PeriodPostoperative PainTreatment OutcomeAnalgesicsAnalgesics, OpioidAnesthetics, LocalLidocaine

Identifiers

PMID30117019
OpenAlexW2887940831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.