ReviewInternational orthopaedics2019
Ossification of the posterior longitudinal ligament in the cervical spine: a review.
Review in International orthopaedics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 5 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Comparative efficacy of contralateral versus ipsilateral open-door laminoplasty for cervical ossification of the posterior longitudinal ligament: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2026Pooled it
- Clinical efficacy and complications of 10 surgical interventions for cervical ossification of the posterior longitudinal ligament: an updated systematic review and network meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Pooled it
- Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review.International journal of molecular sciences · 2022Pooled it
- Potential Link between Ossification of Nuchal Ligament and the Risk of Cervical Ossification of Posterior Longitudinal Ligament: Evidence and Clinical Implication from a Meta-Analysis of 8429 Participants.Orthopaedic surgery · 2021Pooled it
- SATB2 promotes osteogenic differentiation of OPLL-derived posterior longitudinal ligament cells via Wnt/β-catenin signaling in association with RUNX2.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Formaldehyde embalming alters biomechanical strain of human cervical spinal dura mater: quantification and implications from paired fresh-frozen and embalmed specimens.Surgical and radiologic anatomy : SRA · 2026Article
- Evaluation of bone mineral density in patients with cervical ossification of the posterior longitudinal ligament utilizing vertebral bone quality and Hounsfield units.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Biomechanical investigation of spinal cord stress changes following ACAF for different subtypes of cervical OPLL.Scientific reports · 2026Article
- A comparative study on surgical management of long-course symptomatic cervical OPLL between anterior en bloc resection and posterior laminectomy with instrumented fusion.BMC musculoskeletal disorders · 2026Article
- Utility of the fast-field-echo resembling a computed tomography using restricted echo-spacing sequence in evaluating ossification of the posterior longitudinal ligament of the cervical spine.Quantitative imaging in medicine and surgery · 2026Article
- Angiogenesis in ossification of the posterior longitudinal ligament: progress from mechanism to targeted intervention.Frontiers in cell and developmental biology · 2026Review
- Integrin-mediated SPP1 signaling from macrophages orchestrates extracellular matrix remodeling and chondrogenesis in heterotopic ossification.Journal of translational medicine · 2025Article
- Article
- The relationship between OPLL and metabolic disorders.Bone research · 2025Review
- The effects of mechanical stimulation on the morphology and function of spinal ligament cells.BMC musculoskeletal disorders · 2025Article
- AUSS Assisted ACAF Technique in the Treatment of Ossification of the Posterior Longitudinal Ligament Extending to the C2 Segment.Orthopaedic surgery · 2025Article
- Article
- A comparative study on clinical outcomes and safety of accurate anterior cervical ossified posterior longitudinal ligament en bloc resection versus piecemeal resection in patients with ossification of the cervical posterior longitudinal ligament: a propensity score-matching analysis.BMC musculoskeletal disorders · 2025Article
- Spinal hypermobility accelerates ossification in posterior longitudinal ligaments: insights from anFrontiers in physiology · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ossification of the posterior longitudinal ligament (OPLL) is a rare pathologic process of lamellar bone deposition that can result in spinal cord compression. While multiple genetic and environmental factors have been related to the development of OPLL, the pathophysiology remains poorly understood. Asymptomatic patients may be managed conservatively and patients with radiculopathy or myelopathy should be considered for surgical decompression. Multiple studies have demonstrated the morphology and size of the OPLL as well as the cervical alignment have significant implications for the appropriate surgical approach and technique. In this review, we aim to address all the available literature on the etiology, history, presentation, and management of OPLL in an effort to better understand OPLL and give our recommendations for the treatment of patients presenting with OPLL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.