ArticlePsychopharmacology2019
A cFos activation map of remote fear memory attenuation.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 125 citations in OpenAlex.
- The behavioral and neural architecture of observational active avoidance is shaped by demonstrator experience and observer sex.Scientific reports · 2026Article
- Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice.iScience · 2026Article
- Remodeling synaptic connections via engineered neuron-astrocyte interactions.Nature communications · 2026Article
- Role of the hippocampus in systems consolidation of remote fear memory.Experimental & molecular medicine · 2026Review
- Behavioral phenotype analysis highlights sleep heterogeneity and brain cellular activations in a mouse model of PTSD.Neurobiology of stress · 2026Article
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- The thalamic nucleus reuniens orchestrates prefrontal-hippocampal synchrony in memory, emotion, and disease.Frontiers in behavioral neuroscience · 2026Review
- Enhanced Fear Memory in Adult Male C57BL/6 Mice Following Low-Dose Isoflurane Exposure During Juvenile Development.Brain and behavior · 2025Article
- Combinative Protein Expression of Immediate Early Genes c-Fos, Arc, and Npas4 Along Aversive and Appetitive Experience-Related Neural Networks.Hippocampus · 2025Article
- Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents.Neuroscience and biobehavioral reviews · 2025Review
- Prophylactic (R,S)-Ketamine and (2S,6S)-Hydroxynorketamine Decrease Fear Expression by Differentially Modulating Fear Neural Ensembles.Biological psychiatry · 2025Article
- Article
- Multi-region processing during sleep for memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2025Review
- Dissociable dorsal medial prefrontal cortex ensembles are necessary for cocaine seeking and fear conditioning in mice.Translational psychiatry · 2024Article
- Brain-wide mapping of c-Fos expression in nitroglycerin-induced models of migraine.The journal of headache and pain · 2024Article
- Developmental and molecular contributions to contextual fear memory emergence in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Differential recruitment of brain circuits during fear extinction in non-stressed compared to stress resilient animals.Scientific reports · 2024Article
- Article
- Hippocampal Engrams Generate Variable Behavioral Responses and Brain-Wide Network States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The interaction of Synapsin 2a and Synaptogyrin-3 regulates fear extinction in mice.The Journal of clinical investigation · 2024Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
rationaleThe experience of strong traumata leads to the formation of enduring fear memories that may degenerate into post-traumatic stress disorder. One of the most successful treatments for this condition consists of extinction training during which the repeated exposure to trauma-inducing stimuli in a safe environment results in an attenuation of the fearful component of trauma-related memories. While numerous studies have investigated the neural substrates of recent (e.g., 1-day-old) fear memory attenuation, much less is known about the neural networks mediating the attenuation of remote (e.g., 30-day-old) fear memories. Since extinction training becomes less effective when applied long after the original encoding of the traumatic memory, this represents an important gap in memory research.
objectivesHere, we aimed to generate a comprehensive map of brain activation upon effective remote fear memory attenuation in the mouse.
methodsWe developed an efficient extinction training paradigm for 1-month-old contextual fear memory attenuation and performed cFos immunohistochemistry and network connectivity analyses on a set of cortical, amygdalar, thalamic, and hippocampal regions.
resultsRemote fear memory attenuation induced cFos in the prelimbic cortex, the basolateral amygdala, the nucleus reuniens of the thalamus, and the ventral fields of the hippocampal CA1 and CA3. All these structures were equally recruited by remote fear memory recall, but not by the recall of a familiar neutral context.
conclusionThese results suggest that progressive fear attenuation mediated by repetitive exposure is accompanied by sustained neuronal activation and not reverted to a pre-conditioning brain state. These findings contribute to the identification of brain areas as targets for therapeutic approaches against traumatic memories.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.