Evidence map›Paper›PMID 30116787›Full record

ArticleScience advances2018

Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6.

Appu K Singh, Luke L McGoldrick, Edward C Twomey, Alexander I Sobolevsky

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
  2. TRPV6-Mediated CaCancers · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Forty sites of TRP channel regulation.Current opinion in chemical biology · 2025
    Review
  10. The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Review
  13. Bidirectional Allosteric Coupling between PIPInternational journal of molecular sciences · 2024
    Article
  14. CaNature plants · 2024
    Article
  15. Article
  16. Review
  17. Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation.International journal of molecular sciences · 2023
    Review
  18. Article
  19. Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Appu K SinghDepartment of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA.
Luke L McGoldrickDepartment of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA.ORCID 0000-0002-8310-7502
Edward C TwomeyDepartment of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA.ORCID 0000-0002-1855-1586
Alexander I SobolevskyDepartment of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street, New York, NY 10032, USA.ORCID 0000-0001-5181-8644
Columbia University · US

Funding

TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI KIEFT, JEFFREY S · 2012 to 2021
$14.7M
TRAINING IN CELLULAR, MOLECULAR AND BIOPHYSICAL STUDIEST32GM008224 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LIEM, RONALD K. · 1987 to 2021
$9.9M
Structure and Function of AMPA subtype ionotropic glutamate receptorsR01NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KURNIKOVA, MARIA G, SOBOLEVSKY, ALEXANDER · 2013 to 2022
$4.3M
Structure and function of Transient Receptor Potential ChannelsR01CA206573 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2017 to 2026
$3.8M
Structural elucidation of ionotropic glutamate receptor states with cryoelectron microscopyF31NS093838 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TWOMEY, EDWARD C · 2016 to 2017
$84k
NCI NIH HHS R01 CA206573NIGMS NIH HHS P41 GM103310NIGMS NIH HHS T32 GM008224NINDS NIH HHS F31 NS093838NINDS NIH HHS R01 NS083660
6 · The paper itself

Abstract

Calcium (Ca

Indexed as

AnimalsBinding SitesCalciumCalcium ChannelsCalmodulinCryoelectron MicroscopyHumansProtein BindingProtein ConformationRatsTRPV Cation ChannelsCalciumCalcium ChannelsCalmodulinTRPV6 channelTRPV6 protein, humanTRPV Cation Channels

Identifiers

PMID30116787
PMCPMC6093632
OpenAlexW2885153710

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.