ArticleScience advances2018
DNA methylation regulates transcriptional homeostasis of algal endosymbiosis in the coral model Aiptasia.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 126 citations in OpenAlex.
- Bacterial inoculation elicits changes to the coral epigenome.Nature communications · 2026Article
- Coral color morphs exhibit distinct microbial and proteomic profiles linked to stress and immune mechanisms in a changing ocean.Microbiome · 2026Article
- Repressive Cytosine Methylation is a Marker of Viral Gene Transfer Across Divergent Eukaryotes.Molecular biology and evolution · 2025Article
- Integrated approach to explore Anemonia viridis regeneration under a climate change scenario.Scientific reports · 2025Article
- Comparative genome-wide identification and characterization of SET domain-containing and JmjC domain-containing proteins in piroplasms.BMC genomics · 2024Article
- Patterns of methylation and transcriptional plasticity during thermal acclimation in a reef-building coral.Evolutionary applications · 2024Article
- Mixed Patterns of Intergenerational DNA Methylation Inheritance in Acropora.Molecular biology and evolution · 2024Article
- Potential Role of DNA Methylation as a Driver of Plastic Responses to the Environment Across Cells, Organisms, and Populations.Genome biology and evolution · 2024Article
- Associations between DNA methylation and gene regulation depend on chromatin accessibility during transgenerational plasticity.BMC biology · 2023Article
- Potential role of NiScience · 2023Article
- Comparative analysis reveals epigenomic evolution related to species traits and genomic imprinting in mammals.Innovation (Cambridge (Mass.)) · 2023Article
- How to build a lichen: from metabolite release to symbiotic interplay.The New phytologist · 2023Review
- Molecular insights into the Darwin paradox of coral reefs from the sea anemone Aiptasia.Science advances · 2023Article
- Histone modifications and DNA methylation act cooperatively in regulating symbiosis genes in the sea anemone Aiptasia.BMC biology · 2022Article
- Article
- Coral-bleaching responses to climate change across biological scales.Global change biology · 2022Review
- Combined analyses of RNA-sequence and Hi-C along with GWAS loci-A novel approach to dissect keloid disorder genetic mechanism.PLoS genetics · 2022Article
- Changes in gene body methylation do not correlate with changes in gene expression in Anthozoa or Hexapoda.BMC genomics · 2022Article
- A Broad Survey of Gene Body and Repeat Methylation in Cnidaria Reveals a Complex Evolutionary History.Genome biology and evolution · 2022Article
- The Role of DNA Methylation in Genome Defense in Cnidaria and Other Invertebrates.Molecular biology and evolution · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The symbiotic relationship between cnidarians and dinoflagellates is the cornerstone of coral reef ecosystems. Although research has focused on the molecular mechanisms underlying this symbiosis, the role of epigenetic mechanisms, that is, the study of heritable changes that do not involve changes in the DNA sequence, is unknown. To assess the role of DNA methylation in the cnidarian-dinoflagellate symbiosis, we analyzed genome-wide CpG methylation, histone associations, and transcriptomic states of symbiotic and aposymbiotic anemones in the model system Aiptasia. We found that methylated genes are marked by histone 3 lysine 36 trimethylation (H3K36me3) and show significant reduction of spurious transcription and transcriptional noise, revealing a role of DNA methylation in the maintenance of transcriptional homeostasis. Changes in DNA methylation and expression show enrichment for symbiosis-related processes, such as immunity, apoptosis, phagocytosis recognition, and phagosome formation, and reveal intricate interactions between the underlying pathways. Our results demonstrate that DNA methylation provides an epigenetic mechanism of transcriptional homeostasis that responds to symbiosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.