ArticleJournal of diabetes research2018
Effect of Insulin-Induced Lipodystrophy on Glycemic Control among Children and Adolescents with Diabetes in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.
Article in Journal of diabetes research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Adverse Outcomes and Associated Factors Among Children and Youths With Diabetes Mellitus in East Africa: A Systematic Review and Meta-Analysis.Journal of advanced nursing · 2026Pooled it
- Poor glycemic control and its associated factors among type 1 diabetic children in Ethiopia: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Glycemic control among diabetic patients in Ethiopia: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Prevalence of Glycemic Control and Factors Associated With Poor Glycemic Control: A Systematic Review and Meta-analysis.Inquiry : a journal of medical care organization, provision and financingPooled it
- Impacts of insulin storage and injection techniques intervention on glycemic control among patients with diabetes in northwest Ethiopia: a quasi-experimental study.Therapeutic advances in endocrinology and metabolism · 2026Article
- Development of a diagnostic model of insulin-related lipohypertrophy for patients with diabetes mellitus.Journal of diabetes investigation · 2025Article
- Reply to Foster, T.P.; Schatz, D. Comment on "Lombardo et al. The Impact of Insulin-Induced Lipodystrophy on Glycemic Variability in Pediatric Patients with Type 1 Diabetes.Children (Basel, Switzerland) · 2025Article
- Article
- Lipodystrophy With an Uncommon Clinical Presentation in a Patient With Insulin-Requiring Type 2 Diabetes Mellitus.Cureus · 2024Article
- Frequent Self-Monitoring Blood Glucose Correlated to Better Medication Adherence and Glycemic Control in Children with Type 1 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Insulin-induced lipodystrophy and predisposing factors in children and adolescents with type 1 diabetes mellitus (T1DM) in a tertiary care Egyptian center.Acta bio-medica : Atenei Parmensis · 2023Article
- A Hypothesis on the Progression of Insulin-Induced Lipohypertrophy: An Integrated Result of High-Frequency Ultrasound Imaging and Blood Glucose Control of Patients.Diagnostics (Basel, Switzerland) · 2023Article
- The Impact of Insulin-Induced Lipodystrophy on Glycemic Variability in Pediatric Patients with Type 1 Diabetes.Children (Basel, Switzerland) · 2022Article
- Glycemic control among children and adolescents with diabetes in Southern Ethiopia: a cross-sectional study.BMC endocrine disorders · 2022Article
- Gender Differences in Prevalence and Clinical Correlates of Lipohypertrophy in Insulin-Exposed Patients with Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLipodystrophy is one of the clinical complications of insulin injection that affects insulin absorption and leads to poor glycemic control.
objectiveTo assess insulin-induced lipodystrophy and glycemic control.
methodsA cross sectional study was done on 176 diabetic children and adolescents who inject insulin for a minimum of one year. First, anthropometric and clinical characteristics of the patients were recorded in questionnaire, and then observation and palpation techniques were used in assessing lipodystrophy.
resultOut of the total 176 participants, 103 (58.5%) had insulin-induced lipodystrophy, of them 100 (97.1%) had lipohypertrophy and 3 (2.9%) had lipoatrophy. Being younger, failure to rotate the injection site every week and multiple reuse of insulin syringe had significant influence in development of insulin-induced lipohypertrophy. Lipohypertrophy in turn was associated with the use of higher dose of insulin and nonoptimal glycemic control.
conclusionFindings of this study revealed that in spite of using recombinant human insulin, the magnitude of the lipohypertrophy still remained high. Therefore, a routine workup of insulin-injecting patients for such complication is necessary, especially in the individuals who have a nonoptimal glycemic control.
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