ArticleDermatology practical & conceptual2018
Squamous cell carcinoma of the nail unit.
Article in Dermatology practical & conceptual, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Longitudinal Melanonychia as a Rare Sign of Invasive Squamous Cell Carcinoma: Case Report and Systematic Review.Acta dermato-venereologica · 2025Pooled it
- Hidden Beneath the Nail Plate: A Case Report of Subungual Squamous Cell Carcinoma Mimicking Benign Nail Dystrophy.Skin appendage disorders · 2026Article
- Low prevalence of high-risk human papillomavirus in nail unit squamous cell carcinoma in Koreans using next-generation sequencing.JAAD international · 2026Article
- Review
- Causes of Monodactylous Onycholysis in a Diverse Patient Population.International journal of dermatology · 2025Article
- Squamous Cell Carcinoma of the Nail Unit: A Comprehensive Review of Clinical Features, Diagnostic Workflow, Management Strategies and Therapeutic Options.Diagnostics (Basel, Switzerland) · 2025Review
- Review
- Pigmented squamous cell carcinomaJAAD case reports · 2025Article
- Squamous Cell Carcinoma of the Nail Unit: A Case Report.Journal of hand surgery global online · 2025Article
- Update on Squamous Cell Carcinoma of the Nail Unit: An Human Papillomavirus-Associated Condition.Skin appendage disorders · 2024Review
- Nail Unit Squamous Cell Carcinoma with Onycholemmal Features: Case Report and Review of the Literature.Skin appendage disorders · 2023Article
- Longitudinal Melanonychia as the Only Sign of in Situ Squamous Cell Carcinoma.Dermatology practical & conceptual · 2023Article
- Atypical parakeratosis in nail unit squamous cell carcinoma.Journal of cutaneous pathology · 2022Article
- Review
- Squamous cell carcinoma in situ upstaging is not frequent in the nail unit: a tertiary cancer center experience.Archives of dermatological research · 2022Article
- Squamous Cell Carcinoma of the Nail Unit After Trauma: A Case Report.Clinical, cosmetic and investigational dermatology · 2022Article
- Dermoscopic Evaluation of Inflammatory Nail Disorders and Their Mimics.Acta dermato-venereologica · 2021Review
- Squamous Cell Carcinoma of the Nail, an Underdiagnosed and Underestimated Entity: A Series of Two Cases.Cureus · 2021Article
- Subungual Invasive Squamous Cell Carcinoma with Doubtful Underlying Bone Invasion: A Treatment Proposal.Skin appendage disorders · 2021Article
- Diagnosis of Onychomycosis: From Conventional Techniques and Dermoscopy to Artificial Intelligence.Frontiers in medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Squamous cell carcinoma (SCC) of the nail apparatus is a rare malignant tumor that usually originates underneath the nail plate and grows slowly with possible bone invasion. The etiology remains unknown, although a strong association with different conditions, such as high-risk human papillomavirus (HPVs), trauma, or radiation exposure has been demonstrated. Nail SCC is called "the great mimicker nail tumor" because different clinical presentations may coexist, resembling benign or malignant nail lesions. For this reason, there is often a significant delay between the onset of nail SCC and the diagnosis. Clinical manifestation includes onycholysis and erythema, while in the advanced stages nail ulceration can be observed. The association with pain, swelling, and inflammation usually indicates an invasive SCC with involvement of the underlying bone. Metastasis is rare but possible with involvement of lymph nodes. A multidisciplinary approach to assessment, management, and follow-up is advised. Using careful examination and modern diagnostic methods, including onychoscopy, biopsy, and histopathology, will help identify SCC and prevent the invasive progression. X-ray is important to investigate the bone invasion to determine the best surgical approach that will have satisfying cosmetic and functional outcomes. Nevertheless, local excision with sufficient surgical margins, best if using Mohs surgery, is usually sufficient and superior to amputation of the distal phalanx. This review aims to highlight the correct approach in suspected SCC of the nail unit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.