ArticleAnnals of vascular diseases2018
Multiple Roles of Tenascins in Homeostasis and Pathophysiology of Aorta.
Article in Annals of vascular diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Comment on "IFITM1 is required for epithelial mesenchymal transition in airway remodeling of allergic asthma".The World Allergy Organization journal · 2026Article
- Abnormal Distribution and Upregulation of Tenascin-C mRNA Expression in the Liver of 90% Hepatectomy Rats are Related to Post-hepatectomy Liver Failure.Advanced biomedical research · 2026Article
- Genetic Variants in the Extracellular Matrix GeneInternational journal of molecular sciences · 2025Article
- Defining the extracellular matrix for targeted immunotherapy in adult and pediatric brain cancer.NPJ precision oncology · 2025Article
- Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing.Nature communications · 2024Article
- The diagnostic value of tenascin-C in acute aortic syndrome.Journal of geriatric cardiology : JGC · 2024Article
- Advances on the roles of tenascin-C in cancer.Journal of cell science · 2022Article
- The expression and role of tenascin C in abdominal aortic aneurysm formation and progression.Interactive cardiovascular and thoracic surgery · 2022Article
- Langerhans cells and SFRP2/Wnt/beta-catenin signalling control adaptation of skin epidermis to mechanical stretching.Journal of cellular and molecular medicine · 2022Article
- Could we adopt serum Tenascin-C assays to determine prognosis in aortic aneurysms and dissections?Jornal vascular brasileiro · 2021Review
- Tenascin C promotes valvular remodeling in two large animal models of ischemic mitral regurgitation.Basic research in cardiology · 2020Article
- Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm.Experimental & molecular medicine · 2019Review
- Clinical and Molecular Characterization of Classical-Like Ehlers-Danlos Syndrome Due to a NovelGenes · 2019Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Tenascins are a family of large extracellular matrix (ECM) glycoproteins. Four family members (tenascin-C, -R, -X, and -W) have been identified to date. Each member consists of the same types of structural domains and exhibits time- and tissue-specific expression patterns, suggesting their specific roles in embryonic development and tissue remodeling. Among them, the significant involvement of tenascin-C (TNC) and tenascin-X (TNX) in the progression of vascular diseases has been examined in detail. TNC is strongly up-regulated under pathological conditions, induced by a number of inflammatory mediators and mechanical stress. TNC has diverse functions, particularly in the regulation of inflammatory responses. Recent studies suggest that TNC is involved in the pathophysiology of aneurysmal and dissecting lesions, in part by protecting the vascular wall from destructive mechanical stress. TNX is strongly expressed in vascular walls, and its distribution is often reciprocal to that of TNC. TNX is involved in the stability and maintenance of the collagen network and elastin fibers. A deficiency in TNX results in a form of Ehlers-Danlos syndrome (EDS). Although their exact roles in vascular diseases have not yet been elucidated, TNC and TNX are now being recognized as promising biomarkers for diagnosis and risk stratification of vascular diseases.
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