ArticleJournal of occupational medicine and toxicology (London, England)2018
Mutagenic and DNA repair activity in traffic policemen: a case-crossover study.
Article in Journal of occupational medicine and toxicology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Unveiling Urinary Mutagenicity by the Ames Test for Occupational Risk Assessment: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Elevated urinary mutagenicity among those exposed to bituminous coal combustion emissions or diesel engine exhaust.Environmental and molecular mutagenesis · 2021Article
- Epidemiological Research on Occupational and Environmental Carcinogens.International journal of environmental research and public health · 2021Article
- Oxidative stress and DNA damage in agricultural workers after exposure to pesticides.Journal of occupational medicine and toxicology (London, England) · 2021Article
- Biological Monitoring of Exposure to Benzene in Port Workers.Frontiers in public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmissions from vehicles are composed of heterogeneous mixtures of hazardous substances; several pollutants such as Polycyclic Aromatic Hydrocarbons (PAHs) are amongst the most dangerous substances detected in urban monitoring. A cohort of traffic policemen usually occupationally exposed to PAHs present in the urban environment were examined in order to assess the mutagenicity and DNA capacity repair.
methodsSeventy-two urban traffic policemen working in Catania's metropolitan area were enrolled in the study. Two spot urine samples were collected from each subject during the whole working cycle as follows: sample 1 (S1), pre-shift on day 1; sample 2 (S2) post-shift on day 6. 1-hydroxypyrene (1-OHP) was measured to serve as an indirect exposure indicator. Urinary mutagenic activity was assessed through the plate incorporation pre-incubation technique with S9, using YG1024 Salmonella typhimurium strain over-sensitive to PAH metabolite. Concentrations of urinary 8-oxodG were measured using liquid chromatography tandem mass spectrometry.
resultsAs regards the exposure to PAHs, results highlighted a statistically significant difference (
conclusionsThis study demonstrated that occupational exposure to pollutants from traffic emission, assessed via 1-OHP measurements in urine, may lead to DNA repair and mutagenic activity, in line with other studies.
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