Evidence map›Paper›PMID 30116247›Full record

ArticleFrontiers in immunology2018

Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein.

Lucie Potuckova, Lubica Draberova, Ivana Halova, Tomas Paulenda, Petr Draber

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Regulation, targets and functions of CSK.Frontiers in cell and developmental biology · 2023
    Review
  5. Review
  6. Apoptosis regulation by the tyrosine-protein kinase CSK.Frontiers in cell and developmental biology · 2022
    Review
  7. Review
  8. The Role of Mast Cells in IgE-Independent Lung Diseases.Clinical reviews in allergy & immunology · 2020
    Review
  9. Mast Cell Migration and Chemotaxis Assayed by Microscopy.Methods in molecular biology (Clifton, N.J.) · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lucie PotuckovaDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Lubica DraberovaDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Ivana HalovaDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Tomas PaulendaDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Petr DraberDepartment of Signal Transduction, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Czech Academy of Sciences, Institute of Molecular Genetics · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

C-terminal Src kinase (CSK) is a major negative regulator of Src family tyrosine kinases (SFKs) that play critical roles in immunoreceptor signaling. CSK is brought in contiguity to the plasma membrane-bound SFKs

Indexed as

Analysis of VarianceAnimalsBone Marrow CellsCalciumCell DegranulationCSK Tyrosine-Protein KinaseCytokinesFibronectinsGenetic VectorsHEK293 CellsHumansIntercellular Signaling Peptides and ProteinsMast CellsMembrane ProteinsMiceMice, Inbred C57BLCalciumCSK protein, humanCSK Tyrosine-Protein KinaseCytokinesFibronectinsIntercellular Signaling Peptides and Proteinslyn protein-tyrosine kinaseMembrane ProteinsPag1 protein, mousePag protein, mousePhosphoproteinsProtein Tyrosine Phosphatase, Non-Receptor Type 6Ptpn6 protein, mouseReceptors, IgEsrc-Family KinasesSTAT5 Transcription FactorTyrosineC-terminal Src kinasecytokinesdegranulationLYNmast cellphosphoprotein associated with glycosphingolipid-enriched microdomainsSHP-1STAT5

Identifiers

PMID30116247
PMCPMC6082945
OpenAlexW2885107157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.