ArticleFrontiers in physiology2018
Simulation of Stimulation: Cytokine Dosage and Cell Cycle Crosstalk Driving Timing-Dependent T Cell Differentiation.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Beyond the chaos: How architecture structures tumour biology.The FEBS journal · 2026Review
- Deciphering the Immunomodulatory Role of Cyclin-Dependent Kinase 4/6 Inhibitors in the Tumor Microenvironment.International journal of molecular sciences · 2023Review
- Dysregulated metal ion homeostasis underscores non-canonical function of CD8Frontiers in medicine · 2023Article
- T cell phenotype switching in autoimmune disorders: Clinical significance of targeting metabolism.Clinical and translational medicine · 2022Article
- Two heads are better than one: current landscape of integrating QSP and machine learning : An ISoP QSP SIG white paper by the working group on the integration of quantitative systems pharmacology and machine learning.Journal of pharmacokinetics and pharmacodynamics · 2022Review
- Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response.Frontiers in immunology · 2022Article
- An integrative systems biology view of host-pathogen interactions: The regulation of immunity and homeostasis is concomitant, flexible, and smart.Frontiers in immunology · 2022Article
- CpG Oligodeoxynucleotides for Anticancer Monotherapy from Preclinical Stages to Clinical Trials.Pharmaceutics · 2021Review
- A multi-approach and multi-scale platform to model CD4+ T cells responding to infections.PLoS computational biology · 2021Article
- AnSmall methods · 2021Article
- Unfolded Protein Corona Surrounding Nanotubes Influence the Innate and Adaptive Immune System.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Integrative computational approach identifies drug targets in CD4NPJ systems biology and applications · 2021Article
- System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation.Frontiers in immunology · 2021Review
- The transcriptome of anterior regeneration in earthworm Eudrilus eugeniae.Molecular biology reports · 2021Article
- Targeting Mitochondrial-Derived Reactive Oxygen Species in T Cell-Mediated Autoimmune Diseases.Frontiers in immunology · 2021Review
- Continuous Modeling of T CD4 Lymphocyte Activation and Function.Frontiers in immunology · 2021Article
- Co-exposure of sodium arsenite and uranyl acetate differentially alters gene expression in CD3/CD28 activated CD4+ T-cells.Toxicology reports · 2021Article
- Functionally specialized human CD4eLife · 2020Article
- Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines.Open biology · 2020Review
- A Mechanistic Computational Model Reveals That Plasticity of CD4Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Triggering an appropriate protective response against invading agents is crucial to the effectiveness of human innate and adaptive immunity. Pathogen recognition and elimination requires integration of a myriad of signals from many different immune cells. For example, T cell functioning is not qualitatively, but quantitatively determined by cellular and humoral signals. Tipping the balance of signals, such that one of these is favored or gains advantage on another one, may impact the plasticity of T cells. This may lead to switching their phenotypes and, ultimately, modulating the balance between proliferating and memory T cells to sustain an appropriate immune response. We hypothesize that, similar to other intracellular processes such as the cell cycle, the process of T cell differentiation is the result of: (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.